Structure of PDB 7r8b Chain B

Receptor sequence
>7r8bB (length=564) Species: 9606 (Homo sapiens) [Search protein sequence]
DRLFSSESDNSLYFTYSGQPNTLEVRDLNYQVGIQNLSFKVRSGQMLAII
GSSGCGRASLLDVITGRGHGGKIKSGQIWINGQPSSPQLVRKCVAHVRQH
NQLLPNLTVRETLAFIAQMRLPRTFSQAQRDKRVEDVIAELRLRQCADTR
VGNMYVRGLSGGERRRVSIGVQLLWNPGILILDEPTSGLDSFTAHNLVKT
LSRLAKGNRLVLISLHQPRSDIFRLFDLVLLMTSGTPIYLGAAQHMVQYF
TAIGYPCPRYSNPADFYVDLTSIDRRSREQELATREKAQSLAALFLEKVM
PGAVQQFTTLIRRQISNDFRDLPTLLIHGAEACLMSMTIGFLYFGHGSIQ
LSFMDTAALLFMIGALIPFNVILDVISKCYSERAMLYYELEDGLYTTGPY
FFAKILGELPEHCAYIIIYGMPTYWLANLRPGLQPFLLHFLLVWLVVFCC
RIMALAAAALLPTFHMASFFSNALYNSFYLAGGFMINLSSLWTVPAWISK
VSFLRWCFEGLMKIQFSRRTGDKILSVMELDSYPLYAIYLIVIGLSGGFM
VLYYVSLRFIKQKP
3D structure
PDB7r8b Molecular basis of cholesterol efflux via ABCG subfamily transporters.
ChainB
Resolution3.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 7.6.2.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CLR B E423 S469 E331 S377
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
GO:0042626 ATPase-coupled transmembrane transporter activity
GO:0046872 metal ion binding
GO:0046982 protein heterodimerization activity
GO:0046983 protein dimerization activity
GO:0120020 cholesterol transfer activity
GO:0140359 ABC-type transporter activity
Biological Process
GO:0006869 lipid transport
GO:0007584 response to nutrient
GO:0009410 response to xenobiotic stimulus
GO:0010949 negative regulation of intestinal phytosterol absorption
GO:0014850 response to muscle activity
GO:0015914 phospholipid transport
GO:0015918 sterol transport
GO:0030299 intestinal cholesterol absorption
GO:0031667 response to nutrient levels
GO:0033344 cholesterol efflux
GO:0042632 cholesterol homeostasis
GO:0045796 negative regulation of intestinal cholesterol absorption
GO:0055085 transmembrane transport
GO:0055092 sterol homeostasis
GO:0070328 triglyceride homeostasis
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016324 apical plasma membrane
GO:0043190 ATP-binding cassette (ABC) transporter complex
GO:0043235 receptor complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7r8b, PDBe:7r8b, PDBj:7r8b
PDBsum7r8b
PubMed34404721
UniProtQ9H221|ABCG8_HUMAN ATP-binding cassette sub-family G member 8 (Gene Name=ABCG8)

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