Structure of PDB 7r2g Chain B

Receptor sequence
>7r2gB (length=351) Species: 9606 (Homo sapiens) [Search protein sequence]
EQPGLCGLSNLGNTCFMNSAIQCLSNTPPLTEYFLNDKYQEELNFDNPLG
MRGEIAKSYAELIKQMWSGKFSYVTPRAFKTQVGRFAPQFSGYQQQDCQE
LLAFLLDGLHEDLNRIRKKPYIQLKDADGRPDKVVAEEAWENHLKRNDSI
IVDIFHGLFKSTLVCPECAKISVTFDPFCYLTLPLASKVKLKDCIELFTT
KEKLGAEDPWYCPNCKEHQQATKKLDLWSLPPVLVVHLKRFSRDKLDTLV
DFPINDLDMSEFLINPNAGPCRYNLIAVSNHYGGMGGGHYTAFAKNKDDG
KWYYFDDSSVSTASEDQIVSKAAYVLFYQRQDTFSGTGFFPLDRETLEHH
H
3D structure
PDB7r2g Mitoxantrone stacking does not define the active or inactive state of USP15 catalytic domain.
ChainB
Resolution1.98 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.19.12: ubiquitinyl hydrolase 1.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B C419 C422 C780 C783 C165 C168 C212 C215
BS02 MIX B Y855 H862 Y877 D879 Y282 H289 Y304 D306
Gene Ontology
Molecular Function
GO:0004843 cysteine-type deubiquitinase activity
Biological Process
GO:0016579 protein deubiquitination

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Molecular Function
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Biological Process
External links
PDB RCSB:7r2g, PDBe:7r2g, PDBj:7r2g
PDBsum7r2g
PubMed35605756
UniProtQ9Y4E8|UBP15_HUMAN Ubiquitin carboxyl-terminal hydrolase 15 (Gene Name=USP15)

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