Structure of PDB 7qxw Chain B

Receptor sequence
>7qxwB (length=387) Species: 9606 (Homo sapiens) [Search protein sequence]
ASKLPLVTPHTQCRLKLLKLERIKDYLLMEEEFIRNQEQMKPLEEKQEEE
RSKVDDLRGTPMSVGTLEEIIDDNHAIVSTSVGSEHYVSILSFVDKDLLE
PGCSVLLNHKVHAVIGVLMDDTDPLVTVMKVEKAPQETYADIGGLDNQIQ
EIKESVELPLTHPEYYEEMGIKPPKGVILYGPPGTGKTLLAKAVANQTSA
TFLRVVGSELIQKYLGDGPKLVRELFRVAEEHAPSIVFIDEIDAIGTKRY
DSNSGGEREIQRTMLELLNQLDGFDSRGDVKVIMATNRIETLDPALIRPG
RIDRKIEFPLPDEKTKKRIFQIHTSRMTLADDVTLDDLIMAKDDLSGADI
KAICTEAGLMALRERRMKVTNEDFKKSKENVLYKKQE
3D structure
PDB7qxw Mechanism of 26S proteasome activation by the 19S-interacting protein ZFAND5
ChainB
Resolution4.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP B G188 P228 G229 T230 G231 K232 T233 L234 I364 H368 G392 A393 K396 G143 P183 G184 T185 G186 K187 T188 L189 I319 H323 G347 A348 K351
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
GO:0036402 proteasome-activating activity
Biological Process
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:1901800 positive regulation of proteasomal protein catabolic process
Cellular Component
GO:0000502 proteasome complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005838 proteasome regulatory particle
GO:0008540 proteasome regulatory particle, base subcomplex
GO:0016020 membrane
GO:0022624 proteasome accessory complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7qxw, PDBe:7qxw, PDBj:7qxw
PDBsum7qxw
PubMed37595557
UniProtP62191|PRS4_HUMAN 26S proteasome regulatory subunit 4 (Gene Name=PSMC1)

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