Structure of PDB 7qvl Chain B

Receptor sequence
>7qvlB (length=225) Species: 9606 (Homo sapiens) [Search protein sequence]
LSLTADQMVSALLDAEPPILYSEYDRPFSEASMMGLLTNLADRELVHMIN
WAKRVPGFVDLTLHDQVHLLESAWLEILMIGLVWRSMEHPGKLLFAPNLL
LDRNQGKSVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVK
SLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHM
SNKGMEHLYSNVVPSYDLLLEMLDA
3D structure
PDB7qvl Discovery of a Potent and Orally Bioavailable Zwitterionic Series of Selective Estrogen Receptor Degrader-Antagonists.
ChainB
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GZI B M343 L346 L349 A350 D351 E353 L384 F404 M421 G521 H524 L525 V533 P535 L539 M34 L37 L40 A41 D42 E44 L75 F95 M112 G204 H207 L208 V212 P214 L218
External links
PDB RCSB:7qvl, PDBe:7qvl, PDBj:7qvl
PDBsum7qvl
PubMed36727211
UniProtP03372|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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