Structure of PDB 7quv Chain B

Receptor sequence
>7quvB (length=107) Species: 9606 (Homo sapiens) [Search protein sequence]
MSQLERNIETIINTFHQYSVKLGHPDTLNQGEFKELVRKDLQNFLKKENK
NEKVIEHIMEDLDTNADKQLSFEEFIMLMARLTWASHEKMHEGDEGPGHH
HKPGLGE
3D structure
PDB7quv High-affinity peptides developed against calprotectin and their application as synthetic ligands in diagnostic assays.
ChainB
Resolution1.85 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B E15 H22 V26 P31 D32 T33 N71 S77 E79 E9 H16 V20 P25 D26 T27 N65 S71 E73
BS02 CA B D69 N71 D73 Q75 E80 D63 N65 D67 Q69 E74
BS03 CA B S25 L28 H30 T33 E38 S19 L22 H24 T27 E32
Gene Ontology
Molecular Function
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0008017 microtubule binding
GO:0008270 zinc ion binding
GO:0016209 antioxidant activity
GO:0035662 Toll-like receptor 4 binding
GO:0046872 metal ion binding
GO:0048306 calcium-dependent protein binding
GO:0050544 arachidonate binding
GO:0050786 RAGE receptor binding
Biological Process
GO:0002523 leukocyte migration involved in inflammatory response
GO:0002544 chronic inflammatory response
GO:0006914 autophagy
GO:0006915 apoptotic process
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006935 chemotaxis
GO:0006954 inflammatory response
GO:0007267 cell-cell signaling
GO:0010976 positive regulation of neuron projection development
GO:0014002 astrocyte development
GO:0030307 positive regulation of cell growth
GO:0030593 neutrophil chemotaxis
GO:0032119 sequestering of zinc ion
GO:0032496 response to lipopolysaccharide
GO:0034121 regulation of toll-like receptor signaling pathway
GO:0035425 autocrine signaling
GO:0035606 peptidyl-cysteine S-trans-nitrosylation
GO:0035821 modulation of process of another organism
GO:0042742 defense response to bacterium
GO:0043542 endothelial cell migration
GO:0045087 innate immune response
GO:0045113 regulation of integrin biosynthetic process
GO:0050729 positive regulation of inflammatory response
GO:0050832 defense response to fungus
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051493 regulation of cytoskeleton organization
GO:0060264 regulation of respiratory burst involved in inflammatory response
GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide
GO:0070488 neutrophil aggregation
GO:0098869 cellular oxidant detoxification
GO:2001244 positive regulation of intrinsic apoptotic signaling pathway
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0034774 secretory granule lumen
GO:0062023 collagen-containing extracellular matrix
GO:0070062 extracellular exosome
GO:1990660 calprotectin complex
GO:1990662 S100A9 complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7quv, PDBe:7quv, PDBj:7quv
PDBsum7quv
PubMed37198182
UniProtP06702|S10A9_HUMAN Protein S100-A9 (Gene Name=S100A9)

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