Structure of PDB 7qpn Chain B

Receptor sequence
>7qpnB (length=313) Species: 9606 (Homo sapiens) [Search protein sequence]
VKVFRAADPLVGVFLWGVAHSINELSQVPPPVMLLPDDFKASSKIKVNNH
LFHRENLPSHFKFKEYCPQVFRNLRDRFGIDDQDYLVSLTRNPPSESEGS
DGRFLISYDRTLVIKEVSSEDIADMHSNLSNYHQYIVKCHGNTLLPQFLG
MYRVSVDNEDSYMLVMRNMFSHRLPVHRKYDLKGSLVSREASDKEKVKEL
PTLKDMDFLNKNQKVYIGEEEKKIFLEKLKRDVEFLVQLKIMDYSLLLGI
HDIIRGSEPEEEGEFESFIDVYAIRSAEGAPQKEVYFMGLIDILTQHPEQ
YAKRFLDFITNIF
3D structure
PDB7qpn Development of Selective Phosphatidylinositol 5-Phosphate 4-Kinase gamma Inhibitors with a Non-ATP-competitive, Allosteric Binding Mode.
ChainB
Resolution1.95 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.149: 1-phosphatidylinositol-5-phosphate 4-kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ANP B K81 K101 Y103 S156 H163 R190 Y199 K44 K64 Y66 S119 H126 R153 Y162
BS02 DVF B D161 M162 N165 Y169 F185 I373 D374 T377 D124 M125 N128 Y132 F148 I291 D292 T295
Gene Ontology
Molecular Function
GO:0052742 phosphatidylinositol kinase activity
Biological Process
GO:0046488 phosphatidylinositol metabolic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7qpn, PDBe:7qpn, PDBj:7qpn
PDBsum7qpn
PubMed35148092
UniProtQ8TBX8|PI42C_HUMAN Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma (Gene Name=PIP4K2C)

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