Structure of PDB 7qot Chain B

Receptor sequence
>7qotB (length=355) Species: 9606 (Homo sapiens) [Search protein sequence]
CVTQLLKDTCFEGGDITTVFTPSAKYCQVVCTYHPRCLLFTFTAESPSED
PTRWFTCVLKDSVTETLPRVNRTAAISGYSFKQCSHQISACNKDIYVDLD
MKGINYNSSVAKSAQECQERCTDDVHCHFFTYATRQFPSLEHRNICLLKH
TQTGTPTRITKLDKVVSGFSLKSCALSNLACIRDIFPNTVFADSNIDSVM
APDAFVCGRICTHHPGCLFFTFFSQEWPKESQRNLCLLKTSESGLPSTRI
KKSKALSGFSLQSCRHSIPVFCHSSFYHDTDFLGEELDIVAAKSHEACQK
LCTNAVRCQFFTYTPAQASCNEGKGKCYLKLSSNGSPTKILHGRGGISGY
TLRLC
3D structure
PDB7qot Plasma kallikrein structure reveals apple domain disc rotated conformation compared to factor XI.
ChainB
Resolution3.24 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.27: coagulation factor XIa.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B K103 I105 N106 Y107 S109 T132 A134 H143 L148 H151 V166 N196 K102 I104 N105 Y106 S108 T131 A133 H142 L147 H150 V165 N195
Gene Ontology
Cellular Component
GO:0005576 extracellular region

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Biological Process
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Cellular Component
External links
PDB RCSB:7qot, PDBe:7qot, PDBj:7qot
PDBsum7qot
PubMed30801944
UniProtP03951|FA11_HUMAN Coagulation factor XI (Gene Name=F11)

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