Structure of PDB 7qi1 Chain B

Receptor sequence
>7qi1B (length=232) Species: 9606 (Homo sapiens) [Search protein sequence]
MGSMTMDKSELVQKAKLAEQAERYDDMAAAMKAVTEQGHELSNEERNLLS
VAYKNVVGARRSSWRVISSIEQKTERNEKKQQMGKEYREKIEAELQDICN
DVLELLDKYLIPNATQPESKVFYLKMKGDYFRYLSEVASGDNKQTTVSNS
QQAYQEAFEISKKEMQPTHPIRLGLALNFSVFYYEILNSPEKACSLAKTA
FDEAIAELNEESYKDSTLIMQLLRDNLTLWTS
3D structure
PDB7qi1 Macrocycle-stabilization of its interaction with 14-3-3 increases plasma membrane localization and activity of CFTR.
ChainB
Resolution1.76 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B N40 R43 N44 S47 V48 R58 K122 R129 Y130 P167 I168 L174 N175 V178 E182 N226 L229 N43 R46 N47 S50 V51 R61 K125 R132 Y133 P170 I171 L177 N178 V181 E185 N226 L229
BS02 Q95 B A18 E19 A21 E22
BS03 ARG B E19 Y21 N52 E22 Y24 N55
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