Structure of PDB 7qh1 Chain B

Receptor sequence
>7qh1B (length=298) Species: 287 (Pseudomonas aeruginosa) [Search protein sequence]
AEAGGPGGNQKIGKYTYGSDYGPLIVNDRCEMDDGNVITVDMNSSTDDSK
TTPFRFACPTNTYKQVNGAYSPLNDAHFFGGVVFKLYRDWFGTSPLTHKL
YMKVHYGRSVENAYWDGTAMLFGDGATMFYPLVSLDVAAHEVSHGFTEQN
SGLIYRGQSGGMNEAFSDMAGEAAEFYMRGKNDFLIGYDIKKGSGALRYM
DQPSRDGRSIDNASQYYNGIDVHHSSGVYNRAFYLLANSPGWDTRKAFEV
FVDANRYYWTATSNYNSGACGVIRSAQNRNYSAADVTRAFSTVGVTCP
3D structure
PDB7qh1 Chemical Optimization of Selective Pseudomonas aeruginosa LasB Elastase Inhibitors and Their Impact on LasB-Mediated Activation of IL-1 beta in Cellular and Animal Infection Models.
ChainB
Resolution2.74 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.24.26: pseudolysin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B H140 H144 E164 H140 H144 E164
BS02 CI8 B E111 N112 A113 M128 F129 V137 H140 E141 I186 G187 I190 L197 R198 R208 H223 E111 N112 A113 M128 F129 V137 H140 E141 I186 G187 I190 L197 R198 R208 H223
BS03 CA B D136 E172 E175 D183 L185 D136 E172 E175 D183 L185
BS04 CA B Y217 H224 Y217 H224
Gene Ontology
Molecular Function
GO:0004222 metalloendopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:7qh1, PDBe:7qh1, PDBj:7qh1
PDBsum7qh1
PubMed36669138
UniProtP14756|ELAS_PSEAE Elastase (Gene Name=lasB)

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