Structure of PDB 7qg3 Chain B

Receptor sequence
>7qg3B (length=283) Species: 9606 (Homo sapiens) [Search protein sequence]
RFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVK
KLTTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGS
LLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILL
DEAFTAKISDFGLARASVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGV
VLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTS
VEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMT
3D structure
PDB7qg3 Identification and optimisation of a pyrimidopyridone series of IRAK4 inhibitors.
ChainB
Resolution2.11 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 B4U B M192 G193 V200 A211 Y262 Y264 M265 P266 G268 R273 L318 S328 M29 G30 V37 A48 Y93 Y95 M96 P97 G99 R104 L149 S159
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007165 signal transduction

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7qg3, PDBe:7qg3, PDBj:7qg3
PDBsum7qg3
PubMed35439688
UniProtQ9NWZ3|IRAK4_HUMAN Interleukin-1 receptor-associated kinase 4 (Gene Name=IRAK4)

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