Structure of PDB 7qbi Chain B

Receptor sequence

>7qbiB (length=298) Species: 4932 (Saccharomyces cerevisiae)

APSLSNLFYDPTYNPGQSTINYTSIYGNGSTITFDELQGLVNSTVTQAIM
FGVRCGAAALTLIVMWMTSRSRKTPIFIINQVSLFLIILHSALYFKYLLS
NYSSVTYALTGFPQFISRGDVHVYGATNIIQVLLVASIETSLVFQIKVIF
TGDNFKRIGLMLTSISFTLGIATVTMYFVSAVKGMIVTYNDVSATQDKYF
NASTILLASSINFMSFVLVVKLILAIRSRRFLGLKQFDSFHILLIMSCQS
LLVPSIIFILAYSLKPNQGTDVLTTVATLLAVLSLPLSSMWATAANNA

3D structure

• PDB: 7qbi Activation mechanism of the class D fungal GPCR dimer Ste2.
• Chain: B
• Resolution: 3.46 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	B	Q51 H94 Y101 Y128 T131 N132 Q135 Y181 A198 D201 F204 N205 Y266 L268 D275 V276 T279	Q47 H90 Y97 Y124 T127 N128 Q131 Y177 A194 D197 F200 N201 Y262 L264 D271 V272 T275
BS02	Y01	B	A206 I209	A202 I205
BS03	Y01	B	A63 L103	A59 L99
BS04	Y01	B	N46 T50 M54	N42 T46 M50
BS05	Y01	B	L93 K100 G123	L89 K96 G119

Gene Ontology

Molecular Function

• GO:0004930 G protein-coupled receptor activity
• GO:0004932 mating-type factor pheromone receptor activity
• GO:0004934 mating-type alpha-factor pheromone receptor activity
• GO:0005515 protein binding

Biological Process

• GO:0000750 pheromone-dependent signal transduction involved in conjugation with cellular fusion
• GO:0000755 cytogamy
• GO:0007186 G protein-coupled receptor signaling pathway
• GO:0019236 response to pheromone

Cellular Component

• GO:0005886 plasma membrane
• GO:0016020 membrane
• GO:0038038 G protein-coupled receptor homodimeric complex

External links

• PDB: RCSB:7qbi, PDBe:7qbi, PDBj:7qbi
• PDBsum: 7qbi
• PubMed: 35296853
• UniProt: D6VTK4|STE2_YEAST Pheromone alpha factor receptor (Gene Name=STE2)