Structure of PDB 7q0s Chain B

Receptor sequence
>7q0sB (length=620) Species: 9606 (Homo sapiens) [Search protein sequence]
PGLEDWEDEFDLENAVLFEVAWEVANKVGGIYTVLQTKAKVTGDEWGDNY
FLVGPYTEQGVRTQVELLEAPTPALKRTLDSMNSKGCKVYFGRWLIEGGP
LVVLLDVGASAWALERWKGELWDTCNIGVPWYDREANDAVLFGFLTTWFL
GEFLAQSEEKPHVVAHFHEWLAGVGLCLCRARRLPVATIFTTHATLLGRY
LCAGAVDFYNNLENFNVDKEAGERQIYHRYCMERAAAHCAHVFTTVSQIT
AIEAQHLLKRKPDIVTPNGLNVKKFSAFQNLHAQSKARIQEFVRGHFYGH
LDFNLDKTLYFFIAGRYEFSNKGADVFLEALARLNYLLRVNGSEQTVVAF
FIMPARTNNFNVETLKGQAVRKQLWDTANTVKEKFGRKLYESLLVGSLPD
MNKMLDKEDFTMMKRAIFATQRQSFPPVCTHNMLDDSSDPILTTIRRIGL
FNSSADRVKVIFHPEFLSSTSPLLPVDYEEFVRGCHLGVFPSYYEPWGYT
PAECTVMGIPSISTNLSGFGCFMEEHIADPSAYGIYILDRRFRSLDDSCS
QLTSFLYSFCQQSRRQRIIQRNRTERLSDLLDWKYLGRYYMSARHMALSK
AFPEHFTYEPNEADPRPASV
3D structure
PDB7q0s Molecular basis for the regulation of human glycogen synthase by phosphorylation and glucose-6-phosphate.
ChainB
Resolution4.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.1.11: glycogen(starch) synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 G6P B Q294 H297 K301 H501 Q279 H282 K286 H486
Gene Ontology
Molecular Function
GO:0004373 alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity
GO:0005515 protein binding
GO:0005536 D-glucose binding
GO:0016757 glycosyltransferase activity
GO:0061547 glycogen synthase activity, transferring glucose-1-phosphate
Biological Process
GO:0005977 glycogen metabolic process
GO:0005978 glycogen biosynthetic process
GO:0007507 heart development
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016020 membrane
GO:0016234 inclusion body

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7q0s, PDBe:7q0s, PDBj:7q0s
PDBsum7q0s
PubMed35835870
UniProtP13807|GYS1_HUMAN Glycogen [starch] synthase, muscle (Gene Name=GYS1)

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