Structure of PDB 7pxx Chain B

Receptor sequence
>7pxxB (length=265) Species: 5664 (Leishmania major) [Search protein sequence]
TVPVALVTGAAKRLGRSIAEGLHAEGYAVCLHYHRSAAEANALSATLNAR
RPNSAITVQADLSNVATAPAPVTLFTRCAELVAACYTHWGRCDVLVNNAS
SFYPTPLLRREAMETATADLFGSNAIAPYFLIKAFAHRVAGTPAKHRGTN
YSIINMVDAMTNQPLLGYTIYTMAKGALEGLTRSAALELAPLQIRVNGVG
PGLSVLVDDMPPAVWEGHRSKVPLYQRDSSAAEVSDVVIFLCSSKAKYIT
GTCVKVDGGYSLTRA
3D structure
PDB7pxx Crystal structure of the ternary complex of Leishmania major pteridine reductase 1 with the cofactor NADP + /NADPH and the substrate folic acid.
ChainB
Resolution1.81 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.5.1.33: pteridine reductase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FOL B S111 F113 Y194 L226 S100 F102 Y171 L203
BS02 NDP B R17 L18 H36 Y37 H38 R39 S40 L66 N109 A110 S111 S112 M179 Y194 K198 P224 S227 R13 L14 H32 Y33 H34 R35 S36 L62 N98 A99 S100 S101 M156 Y171 K175 P201 S204
Gene Ontology
Molecular Function
GO:0004155 6,7-dihydropteridine reductase activity
GO:0016491 oxidoreductase activity
GO:0047040 pteridine reductase activity
Biological Process
GO:0006729 tetrahydrobiopterin biosynthetic process
GO:0031427 response to methotrexate
Cellular Component
GO:0005829 cytosol

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Cellular Component
External links
PDB RCSB:7pxx, PDBe:7pxx, PDBj:7pxx
PDBsum7pxx
PubMed35400669
UniProtQ01782|PTR1_LEIMA Pteridine reductase 1 (Gene Name=PTR1)

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