Structure of PDB 7pvn Chain B

Receptor sequence

>7pvnB (length=990) Species: 9606 (Homo sapiens)

VEIDDALYSRQRYVLGDTAMQKMAKSHVFLSGMGGLGLEIAKNLVLAGIK
AVTIHDTEKCQAWDLGTNFFLSEDDVVNKRNRAEAVLKHIAELNPYVHVT
SSSVPFNETTDLSFLDKYQCVVLTEMKLPLQKKINDFCRSQCPPIKFISA
DVHGIWSRLFCDFGDEFEVLDTTGEEPKEIFISNITQANPGIVTCLENHP
LETGQFLTFREINGMTGLNGSIQQITVISPFSFSIGDTTELEPYLHGGIA
VQVKTPKTVFFESLERQLKHPKCLIVDFSNPEAPLEIHTAMLALDQFQEK
YSRKPNVGCQQDSEELLKLATSISETLEEKPDVNADIVHWLSWTAQGFLS
PLAAAVGGVASQEVLKAVTGKFSPLCQWLYLEAADIVESLGKPECEEFLP
RGDRYDALRACIGDTLCQKLQNLNIFLVGCGAIGCEMLKNFALLGVGTSK
EKGMITVTDPDLIEKSNLNRQFLFRPHHIQKPKSYTAADATLKINSQIKI
DAHLNKVCPTTETIYNDEFYTKQDVIITALDNVEARRYVDSRCLANLRPL
LDSGTMGTKGHTEVIVPHLTESYNSHRDPPEEEIPFATLKSFPAAIEHTI
QWARDKFESSFSHKPSLFNKFWQTYSSAEEVLQKIQSGHSLEGCFQVIKL
LSRRPRNWSQCVELARLKFEKYFNHKALQLLHCFPLDIRLFWQSPKRPPS
PIKFDLNEPLHLSFLQNAAKLYATVYCIPFAEEDLSADALLNILSEVKIQ
EFKPSNKVSSEDERNAIFQLEKAILSNEATKSDLQMAVLSFEKDDDHNGH
IDFITAASNLRAKMYSIEPADRFKTKRIAGKIIPAIATTTATVSGLVALE
MIKVTGGYPFEAYKNCFLNLAIPIVVFTETTEVRKTKIRNGISFTIWDRW
TVHGKEDFTLLDFINAVKEKYGIEPTMVVQGVKMLYVPVMPGHAKRLKLT
MHKLVKPTTEKKYVDLTVSFAPDIDGDEDLPGPPVRYYFS

3D structure

• PDB: 7pvn Structures of UBA6 explain its dual specificity for ubiquitin and FAT10.
• Chain: B
• Resolution: 2.71 Å

Enzymatic activity

• Enzyme Commision number: 6.2.1.45: E1 ubiquitin-activating enzyme.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ATP	B	D497 P498 N505 R508 K521 K544 V545 A567 L568 D569 N570	D459 P460 N467 R470 K483 K506 V507 A529 L530 D531 N532
BS02	CA	B	D499 E502	D461 E464

Gene Ontology

Molecular Function

• GO:0004792 thiosulfate sulfurtransferase activity
• GO:0004839 ubiquitin activating enzyme activity
• GO:0005515 protein binding
• GO:0005524 ATP binding
• GO:0008641 ubiquitin-like modifier activating enzyme activity
• GO:0016779 nucleotidyltransferase activity
• GO:0016874 ligase activity
• GO:0019780 FAT10 activating enzyme activity

Biological Process

• GO:0006511 ubiquitin-dependent protein catabolic process
• GO:0007612 learning
• GO:0007626 locomotory behavior
• GO:0016567 protein ubiquitination
• GO:0021764 amygdala development
• GO:0021766 hippocampus development
• GO:0032446 protein modification by small protein conjugation
• GO:0036211 protein modification process
• GO:0060996 dendritic spine development

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol

External links

• PDB: RCSB:7pvn, PDBe:7pvn, PDBj:7pvn
• PDBsum: 7pvn
• PubMed: 35970836
• UniProt: A0AVT1|UBA6_HUMAN Ubiquitin-like modifier-activating enzyme 6 (Gene Name=UBA6)