Structure of PDB 7prv Chain B

Receptor sequence

>7prvB (length=321) Species: 9606 (Homo sapiens) [Search protein sequence]

PKLCLVCSDEASGCHYGVLTCGSCKVFFKRAVEGQHNYLCAGRNDCIIDK
IRRKNCPACRYRKCLQAGMNLQLTPTLVSLLEVIEPEVLYAGYDSSVPDS
TWRIMTTLNMLGGRQMIAAVKWAKAIPGFRNLHLDDQMTLLQYSWMSLMA
FALGWRSYRQSSANLLCFAPDLIINEQRMTLPDMYDQCKHMLYVSSELHR
LQVSYEEYLCMKTLLLLSSVPKDGLKSQELFDEIRMTYIKELGKAIVKRE
GNSSQNWQRFYQLTKLLDSMHEVVENLLNYCFQTFLDKTMSIEFPEMLAE
IITNQIPKYSNGNIKKLLFHQ

3D structure

PDB

7prv Quaternary glucocorticoid receptor structure highlights allosteric interdomain communication.

Chain

Resolution

2.7 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	dna	B	G430 C431 H432 Y433 K446 K471	G13 C14 H15 Y16 K29 K54
BS02	dna	B	S440 R447 R470 K471 R477	S23 R30 R53 K54 R60
BS03	ZN	B	C421 C424 C441	C4 C7 C24
BS04	ZN	B	C457 C463 C473 C476	C40 C46 C56 C59
BS05	GW6	B	M560 L563 N564 Q570 M601 M604 A605 R611 F623 Q642 M646 L732 Y735 C736 F749	M105 L108 N109 Q115 M146 M149 A150 R156 F168 Q187 M191 L277 Y280 C281 F294

Gene Ontology

	Molecular Function
GO:0003700	DNA-binding transcription factor activity
GO:0008270	zinc ion binding
GO:0043565	sequence-specific DNA binding

	Biological Process
GO:0006355	regulation of DNA-templated transcription

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Molecular Function

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Biological Process

External links

PDB	RCSB:7prv, PDBe:7prv, PDBj:7prv
PDBsum	7prv
PubMed	36747092
UniProt	P04150\|GCR_HUMAN Glucocorticoid receptor (Gene Name=NR3C1)

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