Structure of PDB 7pp6 Chain B

Receptor sequence

>7pp6B (length=1148) Species: 9606 (Homo sapiens)

NVCSTWGNFHYKTFDGDVFRFPGLCDYNFASDCRGSYKEFAVHLKRGPGQ
AEAPAGVESILLTIKDDTIYLTRHLAVLNGAVVSTPHYSPGLLIEKSDAY
TKVYSRAGLTLMWNREDALMLELDTKFRNHTCGLCGDYNGLQSYSEFLSD
GVLFSPLEFGNMQKINQPDVVCEDPEEEVAPASCSEHRAECERLLTAEAF
ADCQDLVPLEPYLRACQQDRCRCPGGDTCVCSTVAEFSRQCSHAGGRPGN
WRTATLCPKTCPGNLVYLESGSPCMDTCSHLEVSSLCEEHRMDGCFCPEG
TVYDDIGDSGCVPVSQCHCRLHGHLYTPGQEITNDCEQCVCNAGRWVCKD
LPCPGTCALEGGSHITTFDGKTYTFHGDCYYVLAKGDHNDSYALLGELAP
CGSTDKQTCLKTVVLLADKKKNVVVFKSDGSVLLNELQVNLPHVTASFSV
FRPSSYHIMVSMAIGVRLQVQLAPVMQLFVTLDQASQGQVQGLCGNFNGL
EGDDFKTASGLVEATGAGFANTWKAQSSCHDKLDWLDDPCSLNIESANYA
EHWCSLLKKTETPFGRCHSAVDPAEYYKRCKYDTCNCQNNEDCLCAALSS
YARACTAKGVMLWGWREHVCNKDVGSCPNSQVFLYNLTTCQQTCRSLSEA
DSHCLEGFAPVDGCGCPDHTFLDEKGRCVPLAKCSCYGLYLEAGDVVRCV
CRDGRLHCRALSCQTLAAGYYHVCPDGLMDDGRGGCVVEKECPCVHNNDL
YSSGAKIKVDCNTCTCKRGRWVCTQAVCHGTCSIYGSGHYITFDGKYYDF
DGHCSYVAVQDYCGLGSFSIITENVPCGTTGVTCSKAIKIFMGRTELKLE
DKHRVVIQRDEGHHVAYTTREVGQYLVVESSTGIIVIWDKRTTVFIKLAP
SYKGTVCGLCGNFDHRSNNDFTTRDHMVVSSELDFGNSWKEAPTCPDVST
NPEPCSLNPHRRSWAEKQCSILKSSVFSICHSKVDPKPFYEACVHDSCSC
DTGGDCECFCSAVASYAQECTKEGACVFWRTPDLCPIFCDYYNPPHECEW
HYEPCGNRSFETCRTINGIHSNISVSYLEGCYPRCPKDRPIYEEDLKKCV
TADKCGCYVEDTHYPPGASVPTEETCKSCVCTNSSQVVCRPEEGFCYW

3D structure

• PDB: 7pp6 Helical self-assembly of a mucin segment suggests an evolutionary origin for von Willebrand factor tubules.
• Chain: B
• Resolution: 3.4 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	CA	B	N530 N532 L534 D537 D538	N496 N498 L500 D503 D504
BS02	CA	B	D872 N994 D996 R998 N1001 D1002	D794 N912 D914 R916 N919 D920
BS03	CA	B	D49 D171 N173 L175 E180	D15 D137 N139 L141 E146

External links

• PDB: RCSB:7pp6, PDBe:7pp6, PDBj:7pp6
• PDBsum: 7pp6
• PubMed: 35377815
• UniProt: Q02817|MUC2_HUMAN Mucin-2 (Gene Name=MUC2)