Structure of PDB 7pom Chain B

Receptor sequence
>7pomB (length=239) Species: 9606 (Homo sapiens) [Search protein sequence]
SPACAGRFQSPVDIRPQLAAFSPALRPLELLGFQLPPLPELRLRNNGHSV
QLTLPPGLEMALGPGREYRALQLHLHWGAAGRPGSEHTVEGHRFPAEIHV
VHLSTAFARVDEALGRPGGLAVLAAFLEEGPEENSAYEQLLSRLEEIAEE
GSETQVPGLDISALLPSDFSRYFQYEGSLTTPPCAQGVIWTVFQQTVMLS
AKQLHTLSDTLWGPGDSRLQLNFRATQPLNGRVIEASFP
3D structure
PDB7pom Methyl 2-Halo-4-Substituted-5-Sulfamoyl-Benzoates as High Affinity and Selective Inhibitors of Carbonic Anhydrase IX.
ChainB
Resolution1.98 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 4.2.1.1: carbonic anhydrase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B H94 H96 H119 H74 H76 H99
BS02 7VZ B H64 H94 H96 H119 V121 L198 T199 T200 H48 H74 H76 H99 V101 L179 T180 T181
Gene Ontology
Molecular Function
GO:0004089 carbonate dehydratase activity
GO:0008270 zinc ion binding

View graph for
Molecular Function
External links
PDB RCSB:7pom, PDBe:7pom, PDBj:7pom
PDBsum7pom
PubMed35008553
UniProtQ16790|CAH9_HUMAN Carbonic anhydrase 9 (Gene Name=CA9)

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