Structure of PDB 7poc Chain B

Receptor sequence
>7pocB (length=393) Species: 274 (Thermus thermophilus) [Search protein sequence]
SLDLRARVREELERLKREGLYISPKVLEAPQEPVTRVEGREVVNLASNNY
LGFANHPYLKEKARQYLEKWGAGSGAVRTIAGTFTYHVELEEALARFKGT
ESALVLQSGFTANQGVLGALLKEGDVVFSDELNHASIIDGLRLTKATRLV
FRHADVAHLEELLKAHDTDGLKLIVTDGVFSMDGDIAPLDKIVPLAKKYK
AVVYVDDAHGSGVLGEKGKGTVHHFGFHQDPDVVQVATLSKAWAGIGGYA
AGARELKDLLINKARPFLFSTSHPPAVVGALLGALELIEKEPERVERLWE
NTRYFKRELARLGYDTLGSQTPITPVLFGEAPLAFEASRLLLEEGVFAVG
IGFPTVPRGKARIRNIVTAAHTKEMLDKALEAYEKVGKRLGII
3D structure
PDB7poc An Irreversible, Promiscuous and Highly Thermostable Claisen-Condensation Biocatalyst Drives the Synthesis of Substituted Pyrroles
ChainB
Resolution2.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.29: glycine C-acetyltransferase.
2.3.1.47: 8-amino-7-oxononanoate synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PLP B G111 F112 H136 D179 S183 D208 A210 H211 T240 S242 K243 G109 F110 H134 D177 S181 D206 A208 H209 T238 S240 K241
BS02 PLP B S272 T273 S270 T271
Gene Ontology
Molecular Function
GO:0008710 8-amino-7-oxononanoate synthase activity
GO:0008890 glycine C-acetyltransferase activity
GO:0016740 transferase activity
GO:0016746 acyltransferase activity
GO:0030170 pyridoxal phosphate binding
Biological Process
GO:0009058 biosynthetic process
GO:0009102 biotin biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:7poc, PDBe:7poc, PDBj:7poc
PDBsum7poc
PubMed37266354
UniProtQ5SHZ8|BIKB_THET8 8-amino-7-oxononanoate synthase/2-amino-3-ketobutyrate coenzyme A ligase (Gene Name=TTHA1582)

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