Structure of PDB 7plo Chain B

Receptor sequence
>7ploB (length=759) Species: 9606 (Homo sapiens) [Search protein sequence]
RVAKAEEGASYRKVNRVLPRSNMVYNLYEYSVPEDMYQEHINEINAELGV
YETQVPLLFVVNKQLVRHLSGWEAETFALEHLEMRSLAQFSYLEPGSIRH
IYLYHHAQAVFVLDTVRSLYSAEHGLLLEKVPPPKHTFEVRAETDLKTLA
YKEERRGPTLIAVQSSWELKRLASEIPFPLVPICVNYGVLDWQRHGARRM
IRHYLNLDTCLSQAFEMSRYFHIPIGNLPEDISTHNHLLWLSPTARPDLG
GKEADDNCLVMEFDDQATVEINSSGCYSTVCVELDLQNLAVNTILQSHHV
NDMEGADSMGISFDVIQQASLEDMITGGQAASAPASYDETALCSNTFRIL
KSMPALHRTLHNMMKKLFLQLIAEFKRLGSSVIYANFNRIILCTKKRRVE
DAIAYVEYITSSIHSKETFHSLTISFSRCWEFLLWMDPSNYGGIKGKVSS
RIHCGLQDSQKAGGAEDEQENEDDEEERDGEEEEEAEESNVQFLPQAASC
QNYFLMIVSAYIVAVYHCMKDGLRRSAPGSTPVITFSQDYVANELTQSFF
TITQKIQKKVTGSRNSTELSEMFPVLPGSHLLLNNPALEFIKYVCKVLSL
DTNITNQVNKLNRDLLRLVDVGEFSEEAQFRDPCRSYVLPEVICRSCNFC
RDLDLCKDSVLPQWLCSNCQAPYDSSAIEMTLVEVLQKKLMAFTLQDLVC
LKCRGVKETSMPVYCSCAGDFALTIHTQVFMEQIGIFRNIAQHYGMSYLL
ETLEWLLQK
3D structure
PDB7plo A conserved mechanism for regulating replisome disassembly in eukaryotes.
ChainB
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
3.1.11.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B C2221 C2224 C2236 C700 C703 C715
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0008310 single-stranded DNA 3'-5' DNA exonuclease activity
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
GO:0051539 4 iron, 4 sulfur cluster binding
Biological Process
GO:0000082 G1/S transition of mitotic cell cycle
GO:0000278 mitotic cell cycle
GO:0000731 DNA synthesis involved in DNA repair
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication
GO:0006272 leading strand elongation
GO:0006281 DNA repair
GO:0006287 base-excision repair, gap-filling
GO:0006297 nucleotide-excision repair, DNA gap filling
GO:0045004 DNA replication proofreading
GO:0048568 embryonic organ development
GO:0071897 DNA biosynthetic process
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005886 plasma membrane
GO:0008622 epsilon DNA polymerase complex
GO:0031981 nuclear lumen

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7plo, PDBe:7plo, PDBj:7plo
PDBsum7plo
PubMed34700328
UniProtQ07864|DPOE1_HUMAN DNA polymerase epsilon catalytic subunit A (Gene Name=POLE)

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