Structure of PDB 7phf Chain B

Receptor sequence
>7phfB (length=270) Species: 1924,1950,1114943 [Search protein sequence]
TVAARPQQIDALRTLIRLGSLHTPMVVRTAATLRLVDHILAGARTVKALA
ARTDTRPEALLRLIRHLVAIGLLEEDAPGEFVPTEVGELLADDHPAAQRA
WHDLTQAVARADISFTRLPDAIRTGRPTYESIYGKPFYEDLAGRPDLRAS
FDSLMTTTAFAAPARLDVVDVVDFFEPLRKADAIILSFVLLNWPDHDAVR
ILTRCAEALEILIHERDRFFSTLLDLRMLVFLGGALRTREKWDGLAASAG
LVVEVRLVPLDSCLLVLAPA
3D structure
PDB7phf Evolution-inspired engineering of anthracycline methyltransferases.
ChainB
Resolution2.21 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.292: carminomycin 4-O-methyltransferase.
4.1.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAH B Y143 D237 F238 S252 Y138 D173 F174 S187
BS02 VAK B W106 M160 F253 N257 L303 R306 M307 W101 M155 F188 N192 L224 R227 M228
Gene Ontology
Molecular Function
GO:0008168 methyltransferase activity
GO:0008171 O-methyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:7phf, PDBe:7phf, PDBj:7phf
PDBsum7phf
PubMed36874276
UniProtI2N5E8;
Q06528|DNRK_STRPE Carminomycin 4-O-methyltransferase DnrK (Gene Name=dnrK);
Q54527|RDMB_STREF Aclacinomycin 10-hydroxylase RdmB (Gene Name=rdmB)

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