Structure of PDB 7phd Chain B

Receptor sequence
>7phdB (length=328) Species: 1950,1114943 [Search protein sequence]
LRTLIRLGSLHTPMVVRTAATLRLVDHILAGARTVKALAARTDTRPEALL
RLIRHLVAIGLLEGEFVPTEVGELLADDHPAAQRAWHDLTQAVARADISF
TRLPDAIRTGRPTYESIYGKPFYEDLAGRPDLRASFDSLLDQAFDAPAAA
YDWTNVRHVLDVGGGKGGFAAAIARHVSATVLEMAGTVDTARSYLKDEGL
SDRVDVVEGDFFEPLPRKADAIILSFVLLNWPDHDAVRILTRCAEALEPG
GRILIHERAEAPSGGTRTSDLYFSVLDLRMLVFLGGALRTREKWDGLAAS
AGLVVEEVRQLPSPTIPYDLSLLVLAPA
3D structure
PDB7phd Evolution-inspired engineering of anthracycline methyltransferases.
ChainB
Resolution1.53 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.292: carminomycin 4-O-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAM B Y143 R153 L160 F168 G187 E210 M211 G236 D237 F238 S252 F253 Y123 R133 L140 F144 G163 E183 M184 G209 D210 F211 S225 F226
BS02 3VL B W106 F156 L160 D163 A167 F253 N257 Y299 M307 W86 F136 L140 D141 A143 F226 N230 Y272 M280
Gene Ontology
Molecular Function
GO:0008168 methyltransferase activity
GO:0008171 O-methyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:7phd, PDBe:7phd, PDBj:7phd
PDBsum7phd
PubMed36874276
UniProtI2N5E8;
Q06528|DNRK_STRPE Carminomycin 4-O-methyltransferase DnrK (Gene Name=dnrK)

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