Structure of PDB 7pga Chain B

Receptor sequence
>7pgaB (length=339) Species: 1924,1950,1114943 [Search protein sequence]
TVAARPQQIDALRTLIRLGSLHTPMVVRTAATLRLVDHILAGARTVKALA
ARTDTRPEALLRLIRHLVAIGLLEEDAPGEFVPTEVGELLADDHPAAQRA
WHDLTQAVARADISFTRLPDAIRTGRPTYESIYGKPFYEDLAGRPDLRAS
FDSLMTTTAFAAPAAAYDWTNVRHVLDVGGGKGGFAAAIARRAPHVSATV
LEMAGTVDTARSYLKDEGLSDRVDVVEGDFFEPLPRKADAIILSFVLLNW
PDHDAVRILTRCAEALEPGGRILIHERADVDRFFSTLLDLRMLVFLGGAL
RTREKWDGLAASAGLVVEEVRLVSPNVPLDSCLLVLAPA
3D structure
PDB7pga Evolution-inspired engineering of anthracycline methyltransferases.
ChainB
Resolution2.77 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.292: carminomycin 4-O-methyltransferase.
4.1.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAH B Y143 R153 F168 G187 G188 G189 E210 M211 D237 F238 F239 S252 F253 Y138 R148 F160 G179 G180 G181 E202 M203 D229 F230 F231 S244 F245
BS02 VAK B W106 F156 M160 F253 F297 L300 L301 R304 M305 L344 W101 F151 M155 F245 F284 L287 L288 R291 M292 L329
Gene Ontology
Molecular Function
GO:0008168 methyltransferase activity
GO:0008171 O-methyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:7pga, PDBe:7pga, PDBj:7pga
PDBsum7pga
PubMed36874276
UniProtI2N5E8;
Q06528|DNRK_STRPE Carminomycin 4-O-methyltransferase DnrK (Gene Name=dnrK);
Q54527|RDMB_STREF Aclacinomycin 10-hydroxylase RdmB (Gene Name=rdmB)

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