Structure of PDB 7pg3 Chain B

Receptor sequence

>7pg3B (length=822) Species: 9606 (Homo sapiens)

HLYPGEVCPGMDIRNNLTRLHELENCSVIEGHLQILLMFKTRPEDFRDLS
FPKLIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYALVIFEMVH
LKELGLYNLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNYIVLNKD
DNEECGDICPGTNCPATQFVERCWTHSHCQKVCPTICKSHGCTAEGLCCH
SECLGNCSQPDDPTKCVACRNFYLDGRCVETCPPPYYHFQDWRCVNFSFC
QDLHHKCKCHQYVIHNNKCIPECPSGYTMNSSNLLCTPCLGPCPKVCHLL
EGEKTIDSVTSAQELRGCTVINGSLIINIRGGNNLAAELEANLGLIEEIS
GYLKIRRSYALVSLSFFRKLRLIRGETLEIGNYSFYALDNQNLRQLWDWS
KHNLTITQGKLFFHYNPKLCLSEIHKMEEVSGTKGRQERNDIALKTNGDQ
ASCENELLKFSYIRTSFDKILLRWEPYWPPDFRDLLGFMLFYKEAPYQNV
TEFDGQDACGSNSWTVVDIDPPLRQNHPGWLMRGLKPWTQYAIFVKTLVT
FSDERRTYGAKSDIIYVQTDATNPSVPLDPISVSNSSSQIILKWKPPSDP
NGNITHYLVFWERQAEDSELFELDYCYEDSAGECCSCPKTDSQILKELEE
SSFRKTFEDYLHNVVFVPRPHRPFEKVVNKESLVISGLRHFTGYRIELQA
CNQDTPEERCSVAAYVSARTMPEAKADDIVGPVTHEIFENNVVHLMWQEP
KEPNGLIVLYEVSYRRYGDEELHLCVSRKHFALERGCRLRGLSPGNYSVR
IRATSLAGNGSWTEPTYFYVTD

3D structure

• PDB: 7pg3 Structural Investigations of Full-Length Insulin Receptor Dynamics and Signalling.
• Chain: B
• Resolution: 7.3 Å

Enzymatic activity

• Enzyme Commision number: 2.7.10.1: receptor protein-tyrosine kinase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	B	D707 H710 N711 F714 V715 P716 R717	D659 H662 N663 F666 V667 P668 R669
BS02	peptide	B	P495 F497 R539 F714 V715	P480 F482 R524 F666 V667
BS03	peptide	B	R14 Q34 L36 L37 F64 F88	R14 Q34 L36 L37 F64 F88
BS04	peptide	B	L37 F39 F64 R65 E97	L37 F39 F64 R65 E97
BS05	peptide	B	L486 R488 D535 P537 P549 G550 W551	L471 R473 D520 P522 P528 G529 W530
BS06	peptide	B	R479 D483 K484 R554 E681 C683	R464 D468 K469 R533 E633 C635

Gene Ontology

Molecular Function

• GO:0004672 protein kinase activity
• GO:0004713 protein tyrosine kinase activity
• GO:0004714 transmembrane receptor protein tyrosine kinase activity
• GO:0005524 ATP binding
• GO:0043548 phosphatidylinositol 3-kinase binding
• GO:0043560 insulin receptor substrate binding

Biological Process

• GO:0006468 protein phosphorylation
• GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway
• GO:0046777 protein autophosphorylation

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:7pg3, PDBe:7pg3, PDBj:7pg3
• PDBsum: 7pg3
• PubMed: 35074483
• UniProt: P06213|INSR_HUMAN Insulin receptor (Gene Name=INSR)