Structure of PDB 7pg0 Chain B

Receptor sequence

>7pg0B (length=822) Species: 9606 (Homo sapiens)

HLYPGEVCPGMDIRNNLTRLHELENCSVIEGHLQILLMFKTRPEDFRDLS
FPKLIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYALVIFEMVH
LKELGLYNLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNYIVLNKD
DNEECGDICPGTNCPATQFVERCWTHSHCQKVCPTICKSHGCTAEGLCCH
SECLGNCSQPDDPTKCVACRNFYLDGRCVETCPPPYYHFQDWRCVNFSFC
QDLHHKCKCHQYVIHNNKCIPECPSGYTMNSSNLLCTPCLGPCPKVCHLL
EGEKTIDSVTSAQELRGCTVINGSLIINIRGGNNLAAELEANLGLIEEIS
GYLKIRRSYALVSLSFFRKLRLIRGETLEIGNYSFYALDNQNLRQLWDWS
KHNLTITQGKLFFHYNPKLCLSEIHKMEEVSGTKGRQERNDIALKTNGDQ
ASCENELLKFSYIRTSFDKILLRWEPYWPPDFRDLLGFMLFYKEAPYQNV
TEFDGQDACGSNSWTVVDIDPPLRQNHPGWLMRGLKPWTQYAIFVKTLVT
FSDERRTYGAKSDIIYVQTDATNPSVPLDPISVSNSSSQIILKWKPPSDP
NGNITHYLVFWERQAEDSELFELDYCYEDSAGECCSCPKTDSQILKELEE
SSFRKTFEDYLHNVVFVPRPHRPFEKVVNKESLVISGLRHFTGYRIELQA
CNQDTPEERCSVAAYVSARTMPEAKADDIVGPVTHEIFENNVVHLMWQEP
KEPNGLIVLYEVSYRRYGDEELHLCVSRKHFALERGCRLRGLSPGNYSVR
IRATSLAGNGSWTEPTYFYVTD

3D structure

• PDB: 7pg0 Structural Investigations of Full-Length Insulin Receptor Dynamics and Signalling.
• Chain: B
• Resolution: 7.6 Å

Enzymatic activity

• Enzyme Commision number: 2.7.10.1: receptor protein-tyrosine kinase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	B	D496 D707 H710 N711 F714 V715 P716 R717 P718	D481 D659 H662 N663 F666 V667 P668 R669 P670
BS02	peptide	B	W493 P494 P495 D496 F497 R498 R539 V713 F714 V715 P718	W478 P479 P480 D481 F482 R483 R524 V665 F666 V667 P670
BS03	peptide	B	Q34 L36 L37 F39 L62 F64 F88 F89 R118	Q34 L36 L37 F39 L62 F64 F88 F89 R118
BS04	peptide	B	M38 F64 R65 Y67 F96 E97	M38 F64 R65 Y67 F96 E97
BS05	peptide	B	R488 D535 N547 H548 P549 G550 W551 R554	R473 D520 N526 H527 P528 G529 W530 R533
BS06	peptide	B	Y477 R479 S481 F482 D483 K484 L486 R554 G555 A679 G680	Y462 R464 S466 F467 D468 K469 L471 R533 G534 A631 G632

Gene Ontology

Molecular Function

• GO:0004672 protein kinase activity
• GO:0004713 protein tyrosine kinase activity
• GO:0004714 transmembrane receptor protein tyrosine kinase activity
• GO:0005524 ATP binding
• GO:0043548 phosphatidylinositol 3-kinase binding
• GO:0043560 insulin receptor substrate binding

Biological Process

• GO:0006468 protein phosphorylation
• GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway
• GO:0046777 protein autophosphorylation

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:7pg0, PDBe:7pg0, PDBj:7pg0
• PDBsum: 7pg0
• PubMed: 35074483
• UniProt: P06213|INSR_HUMAN Insulin receptor (Gene Name=INSR)