Structure of PDB 7pcm Chain B

Receptor sequence
>7pcmB (length=341) Species: 271848 (Burkholderia thailandensis E264) [Search protein sequence]
NDLIYQDEHASLQPLEGRTVAVIGYGIQGRAFAANLRDSGVAVRVGNIDD
RYFELARAEGHRVTNIAEAVAHADIVLLLIPDEAHGAVFDVDIAPNLRDG
ALLCVAHGHSLVQGDVRPLPGRDLAMLAPRMYGDPIRRYYLAGQGAPAYF
DIVADHTGRARDRVLAIARAVGFTRAGVMALGYRQETFLDLFQEQFLAPA
LVDLVETGFQVLVERGFNPKAALLEVYGSGEMGKMMLDGADIGLDEVVAL
QGSPTCQVGYHRWRGRTLPTAVRELAARVLDQIEGGDFSAYLKEQASNDY
ASLDDARRAALKRPLNVAHAQVRAAFRFPTEAAGGLYQAAQ
3D structure
PDB7pcm Pathogenic bacteria remodel central metabolic enzyme to build a cyclopropanol warhead.
ChainB
Resolution2.05 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 1.1.1.86: ketol-acid reductoisomerase (NADP(+)).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 7I3 B D191 E195 D190 E194
BS02 7I3 B E232 G253 S254 C257 E231 G252 S253 C256
BS03 NAI B G25 G27 I28 Q29 N48 D51 Y53 L80 I81 P82 D83 A85 H108 Y133 G24 G26 I27 Q28 N47 D50 Y52 L79 I80 P81 D82 A84 H107 Y132
BS04 MG B D191 E195 D190 E194
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004455 ketol-acid reductoisomerase activity
GO:0016491 oxidoreductase activity
GO:0046872 metal ion binding
Biological Process
GO:0008652 amino acid biosynthetic process
GO:0009082 branched-chain amino acid biosynthetic process
GO:0009097 isoleucine biosynthetic process
GO:0009099 L-valine biosynthetic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7pcm, PDBe:7pcm, PDBj:7pcm
PDBsum7pcm
PubMed35906404
UniProtQ2T3G7

[Back to BioLiP]