Structure of PDB 7p46 Chain B

Receptor sequence
>7p46B (length=281) Species: 190485 (Xanthomonas campestris pv. campestris str. ATCC 33913) [Search protein sequence]
NLRDLEPGIHTDLEGRLTYGGYLRLDQLLSAQQPLSEPAHHDEMLFIIQS
QTSELWLKLLAHELRAAIVHLQRDEVWQCRKVLARSKQVLRQLTEQWSVL
ETLTPSEYMGFRDVLGPSSGFQSLQYRYIEFLLGNKNPQMLQVFAYDPAG
QARLREVLEAPSLYEEFLRYLARFGHAIPQQYQARDWTAAHVADDTLRPV
FERIYENTDRYWREYSLCEDLVDVETQFQLWRFRHMRTVMRVIGFKRGTG
GSSGVGFLQQALALTFFPELFDVRTSVGVDN
3D structure
PDB7p46 Binding of l-kynurenine to X. campestris tryptophan 2,3-dioxygenase.
ChainB
Resolution1.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.13.11.11: tryptophan 2,3-dioxygenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HEM B S55 W102 S124 G125 F126 Y131 R132 H240 V244 G253 G255 S257 S50 W97 S119 G120 F121 Y126 R127 H235 V239 G248 G250 S252
BS02 KYN B F51 S55 Y113 R117 S123 G253 T254 F46 S50 Y108 R112 S118 G248 T249
BS03 TRP B Y220 S221 E224 D228 Y215 S216 E219 D223
BS04 TRP B K86 A89 K81 A84
Gene Ontology
Molecular Function
GO:0004833 tryptophan 2,3-dioxygenase activity
GO:0020037 heme binding
GO:0046872 metal ion binding
GO:0051213 dioxygenase activity
Biological Process
GO:0006569 tryptophan catabolic process
GO:0019441 tryptophan catabolic process to kynurenine
GO:0019442 tryptophan catabolic process to acetyl-CoA

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Molecular Function
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Biological Process
External links
PDB RCSB:7p46, PDBe:7p46, PDBj:7p46
PDBsum7p46
PubMed34571402
UniProtQ8PDA8|T23O_XANCP Tryptophan 2,3-dioxygenase (Gene Name=kynA)

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