Structure of PDB 7p3g Chain B

Receptor sequence
>7p3gB (length=344) Species: 9606 (Homo sapiens) [Search protein sequence]
SFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQG
EIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITM
QCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFG
GVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDR
PFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKME
DDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLY
VWDLECTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDR
3D structure
PDB7p3g Diverse, Potent, and Efficacious Inhibitors That Target the EED Subunit of the Polycomb Repressive Complex 2 Methyltransferase.
ChainB
Resolution2.39 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 52R B F97 Y148 N194 K211 D310 Y365 M366 R367 R414 F17 Y68 N114 K131 D223 Y278 M279 R280 R319
External links
PDB RCSB:7p3g, PDBe:7p3g, PDBj:7p3g
PDBsum7p3g
PubMed34807608
UniProtO75530|EED_HUMAN Polycomb protein EED (Gene Name=EED)

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