Structure of PDB 7p0o Chain B

Receptor sequence
>7p0oB (length=66) Species: 9606 (Homo sapiens) [Search protein sequence]
NKAMINLHIQKDNPKIVHAFDMEDLGDKAVYCRCWRSKKFPFCDGAHTKH
NEETGDNVGPLIIKKK
3D structure
PDB7p0o An anti-diabetic drug targets NEET (CISD) proteins through destabilization of their [2Fe-2S] clusters.
ChainB
Resolution1.65 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.6.1.3: cysteine transaminase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FES B C72 R73 C74 C83 D84 G85 H87 P100 C32 R33 C34 C43 D44 G45 H47 P60
BS02 49I B K68 D84 G85 I102 K104 K28 D44 G45 I62 K64
BS03 4OY B K55 V57 K15 V17
Gene Ontology
Molecular Function
GO:0051537 2 iron, 2 sulfur cluster binding
Biological Process
GO:0010506 regulation of autophagy
Cellular Component
GO:0043231 intracellular membrane-bounded organelle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7p0o, PDBe:7p0o, PDBj:7p0o
PDBsum7p0o
PubMed35538231
UniProtQ9NZ45|CISD1_HUMAN CDGSH iron-sulfur domain-containing protein 1 (Gene Name=CISD1)

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