Structure of PDB 7oy1 Chain B

Receptor sequence
>7oy1B (length=340) Species: 1924,1950,1114943 [Search protein sequence]
DALRTLIRLGSLHTPMVVRTAATLRLVDHILAGARTVKALAARTDTRPEA
LLRLIRHLVAIGLLEEDAPGEFVPTEVGELLADDHPAAQRAWHDLTQAVA
RADISFTRLPDAIRTGRPTYESIYGKPFYEDLAGRPDLRASFDSLMATEE
EAVDEAPAAAYDWTNVRHVLDVGGGNGGFAAAIARRAPHVSATVLEMAGT
VDTARSYLKDEGLSDRVDVVEGDFFEPLPRKADAIILSFVLLNWPDHDAV
RILTRCAEALEPGGRILIHERADVEGDGADRFFSTLLDLRMLVFLGGALR
TREKWDGLAASAGLVVEEVRGPLVSPNVPLDSSLLVLAPA
3D structure
PDB7oy1 Evolution-inspired engineering of anthracycline methyltransferases.
ChainB
Resolution2.39 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.1.1.292: carminomycin 4-O-methyltransferase.
4.1.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAH B Y143 R153 M160 G187 G188 E210 M211 G236 D237 F238 S252 Y129 R139 M146 G173 G174 E196 M197 G222 D223 F224 S238
BS02 3VL B F156 M160 T162 F253 N257 L300 L301 R304 M305 F142 M146 T148 F239 N243 L286 L287 R290 M291
Gene Ontology
Molecular Function
GO:0008168 methyltransferase activity
GO:0008171 O-methyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:7oy1, PDBe:7oy1, PDBj:7oy1
PDBsum7oy1
PubMed36874276
UniProtI2N5E8;
Q06528|DNRK_STRPE Carminomycin 4-O-methyltransferase DnrK (Gene Name=dnrK);
Q54527|RDMB_STREF Aclacinomycin 10-hydroxylase RdmB (Gene Name=rdmB)

[Back to BioLiP]