Structure of PDB 7owu Chain B

Receptor sequence

>7owuB (length=395) Species: 9606 (Homo sapiens) [Search protein sequence]

GQGPAKTMEEASKRSYQFWDTQPVPKLGEVVNTHGPVEPDKDNIRQEPYT
LPQGFTWDALDLGDRGVLKELYTLLNENYVEDDDNMFRFDYSPEFLLWAL
RPPGWLPQWHCGVRVVSSRKLVGFISAIPANIHIYDTEKKMVEINFLCVH
KKLRSKRVAPVLIREITRRVHLEGIFQAVYTAGVVLPKPVGTCRYWHRSL
NPRKLIEVKFSHLSRNMTMQRTMKLYRLPETPKTAGLRPMETKDIPVVHQ
LLTRYLKQFHLTPVMSQEEVEHWFYPQENIIDTFVVENANGEVTDFLSFY
TLPSTIMNHPTHKSLKAAYSFYNVHTQTPLLDLMSDALVLAKMKGFDVFN
ALDLMENKTFLEKLKFGIGDGNLQYYLYNWKCPSMGAEKVGLVLQ

3D structure

PDB

7owu Structural and Large-scale Analysis Unveil the Intertwined Paths Promoting NMT-catalyzed Lysine and Glycine Myristoylation.

Chain

Resolution

2.08 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.3.1.-
2.3.1.97: glycylpeptide N-tetradecanoyltransferase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	B	Y180 D183 D185 M187 F188 F190 T282 Y296 H298 F311 H313 S405 I469 G470 D471 Q496	Y79 D82 D84 M86 F87 F89 T181 Y195 H197 F210 H212 S304 I368 G369 D370 Q395
BS02	COA	B	R115 Y117 F119 W120 L248 V250 R255 R258 A260 P261 V285 L287	R14 Y16 F18 W19 L147 V149 R154 R157 A159 P160 V184 L186

Gene Ontology

	Molecular Function
GO:0004379	glycylpeptide N-tetradecanoyltransferase activity

	Biological Process
GO:0006499	N-terminal protein myristoylation

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:7owu, PDBe:7owu, PDBj:7owu
PDBsum	7owu
PubMed	36181773
UniProt	P30419\|NMT1_HUMAN Glycylpeptide N-tetradecanoyltransferase 1 (Gene Name=NMT1)

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