Structure of PDB 7owq Chain B

Receptor sequence

>7owqB (length=388) Species: 9606 (Homo sapiens)

GPAKTMEEASKRSYQFWDTQPVPKLGEVVNTHGPVEPDKDNIRQEPYTLP
QGFTWDALDLGDRGVLKELYTLLNENYVEDDDNMFRFDYSPEFLLWALRP
PGWLPQWHCGVRVVSSRKLVGFISAIPANIHIYDTEKKMVEINFLCVHKK
LRSKRVAPVLIREITRRVHLEGIFQAVYTAGVVLPKPVGTCRYWHRSLNP
RKLIEVKFSHLSRNMTMQRTMKLYRLPETPKTAGLRPMETKDIPVVHQLL
TRYLKQFHLTPVMSQEEVEHWFYPQENIIDTFVVENANGEVTDFLSFYTL
PSTIMKSLKAAYSFYNVHTQTPLLDLMSDALVLAKMKGFDVFNALDLMEN
KTFLEKLKFGIGDGNLQYYLYNWKCPSMGAEKVGLVLQ

3D structure

• PDB: 7owq Structural and Large-scale Analysis Unveil the Intertwined Paths Promoting NMT-catalyzed Lysine and Glycine Myristoylation.
• Chain: B
• Resolution: 3.0 Å

Enzymatic activity

• Enzyme Commision number: 2.3.1.-
  2.3.1.97: glycylpeptide N-tetradecanoyltransferase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	B	V181 D183 F188 F190 N246 T282 Y296 H298 S405 Y420 I469 G470 D471 G472	V78 D80 F85 F87 N143 T179 Y193 H195 S302 Y312 I361 G362 D363 G364
BS02	MYA	B	Y117 F119 W120 N179 V181 I245 L248 C249 V250 R255 S256 A260 I264 T268 A279 Y281 Y479	Y14 F16 W17 N76 V78 I142 L145 C146 V147 R152 S153 A157 I161 T165 A176 Y178 Y371

Gene Ontology

Molecular Function

• GO:0004379 glycylpeptide N-tetradecanoyltransferase activity

Biological Process

• GO:0006499 N-terminal protein myristoylation

External links

• PDB: RCSB:7owq, PDBe:7owq, PDBj:7owq
• PDBsum: 7owq
• PubMed: 36181773
• UniProt: P30419|NMT1_HUMAN Glycylpeptide N-tetradecanoyltransferase 1 (Gene Name=NMT1)