Structure of PDB 7ouh Chain B

Receptor sequence

>7ouhB (length=278) Species: 33747 (Simian T-lymphotropic virus 1)

SPAKLHSFTHCGQAALTLHGATTTEALNILHSCHACRKNNPQHQMPRGHI
RRGLLPNHIWQGDITHFKYKNTLYRLHVWVDTFSGSVSATHKKRETSSEA
ISSLLHAIAHLGRPSHINTDNGPAYASQEFQHACTSLAIRHTTHIPYNPT
SSGLVERTNGILKTLLYKYFSDNPNLPMDNALSVALWTINHLNVLTHCQK
TRWQLHHSPRLPPIPEEKPVTTSKTHWYYFKIPGLNSRQWKGPQRALQEA
AGAALIPVSDTAAQWIPWKLLKRAVCPR

3D structure

• PDB: 7ouh Structural basis for the inhibition of HTLV-1 integration inferred from cryo-EM deltaretroviral intasome structures.
• Chain: B
• Resolution: 3.5 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	B	R39 N42 Q44 K274	R37 N40 Q42 K272
BS02	dna	B	T25 T26 P43 H45	T23 T24 P41 H43
BS03	dna	B	G50 H51 I52 R53 R54 T144 H146 I147 N150 T152 S153 L156 R159 T198 R204 Q250 A252 A253 G254 W267	G48 H49 I50 R51 R52 T142 H144 I145 N148 T150 S151 L154 R157 T196 R202 Q248 A250 A251 G252 W265
BS04	dna	B	T67 E158	T65 E156
BS05	ZN	B	H8 H12 C35	H6 H10 C33
BS06	MG	B	D65 D122	D63 D120
BS07	MG	B	D65 E158	D63 E156
BS08	KLQ	B	D65 D122 N123 P151 E158	D63 D120 N121 P149 E156

Gene Ontology

Molecular Function

• GO:0003676 nucleic acid binding
• GO:0008270 zinc ion binding

Biological Process

• GO:0015074 DNA integration

External links

• PDB: RCSB:7ouh, PDBe:7ouh, PDBj:7ouh
• PDBsum: 7ouh
• PubMed: 34404793
• UniProt: Q4QY51