Structure of PDB 7oug Chain B

Receptor sequence

>7ougB (length=278) Species: 33747 (Simian T-lymphotropic virus 1)

SPAKLHSFTHCGQAALTLHGATTTEALNILHSCHACRKNNPQHQMPRGHI
RRGLLPNHIWQGDITHFKYKNTLYRLHVWVDTFSGSVSATHKKRETSSEA
ISSLLHAIAHLGRPSHINTDNGPAYASQEFQHACTSLAIRHTTHIPYNPT
SSGLVERTNGILKTLLYKYFSDNPNLPMDNALSVALWTINHLNVLTHCQK
TRWQLHHSPRLPPIPEEKPVTTSKTHWYYFKIPGLNSRQWKGPQRALQEA
AGAALIPVSDTAAQWIPWKLLKRAVCPR

3D structure

• PDB: 7oug Structural basis for the inhibition of HTLV-1 integration inferred from cryo-EM deltaretroviral intasome structures.
• Chain: B
• Resolution: 3.1 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	B	R39 N42 Q44 K274	R37 N40 Q42 K272
BS02	dna	B	T26 P43 R49	T24 P41 R47
BS03	dna	B	G50 H51 I52 R53 R54 T144 H146 I147 N150 T152 S153 G155 L156 R159 T198 R204 Q250 A252 A253 W267	G48 H49 I50 R51 R52 T142 H144 I145 N148 T150 S151 G153 L154 R157 T196 R202 Q248 A250 A251 W265
BS04	ZN	B	H8 H12 C35	H6 H10 C33
BS05	MG	B	D65 D122	D63 D120
BS06	MG	B	D65 E158	D63 E156
BS07	RLT	B	D65 D122 Y149 P151 E158	D63 D120 Y147 P149 E156

Gene Ontology

Molecular Function

• GO:0003676 nucleic acid binding
• GO:0008270 zinc ion binding

Biological Process

• GO:0015074 DNA integration

External links

• PDB: RCSB:7oug, PDBe:7oug, PDBj:7oug
• PDBsum: 7oug
• PubMed: 34404793
• UniProt: Q4QY51