Structure of PDB 7ou2 Chain B

Receptor sequence
>7ou2B (length=650) Species: 562 (Escherichia coli) [Search protein sequence]
YLRLKAQHPEILLFYRMGDFYELFYDDAKRASQLLDISLTPMAGIPYHAV
ENYLAKLVNQGESVAICEKVVRIVTPGTISDEALLQERQDNLLAAIWQDS
KGFGYATLDISSGRFRLSEPADRETMAAELQRTNPAELLYAEDFAEMSLI
EGRRGLRRRPLWEFEIDTARQQLNLQFGTRDLVGFGVENAPRGLCAAGCL
LQYAKDTQRTTLPHIRSITMEREQDSIIMDAATRRNLEITQNLAGGAENT
LASVLDCTVTPMGSRMLKRWLHMPVRDTRVLLERQQTIGALQDFTAGLQP
VLRQVGDLERILARLALRTARPRDLARMRHAFQQLPELRAQLETVDSAPV
QALREKMGEFAELRDLLERAIIALALEKQLYEELFDLLLPHLEALQQSAS
ALAELDVLVNLAERAYTLNYTCPTFIDKPGIRITEGRHPVVEQVLNEPFI
ANPLNLSPQRRMLIITGPNMGGKSTYMRQTALIALMAYIGSYVPAQKVEI
GPIDRIFTRVGAADDLRSTFMVEMTETANILHNATEYSLVLMDEIGRGTS
TYDGLSLAWACAENLANKIKALTLFATHYFELTQLPEKMEGVANVHLDAL
EHGDTIAFMHSVQDGAASKSYGLAVAALAGVPKEVIKRARQKLRELESIS
3D structure
PDB7ou2 Cryogenic electron microscopy structures reveal how ATP and DNA binding in MutS coordinates sequential steps of DNA mismatch repair.
ChainB
Resolution4.8 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP B L592 F596 M617 G619 K620 S621 H760 L445 F449 M470 G472 K473 S474 H610
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003684 damaged DNA binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008301 DNA binding, bending
GO:0016887 ATP hydrolysis activity
GO:0030983 mismatched DNA binding
GO:0032136 adenine/cytosine mispair binding
GO:0042802 identical protein binding
GO:0043531 ADP binding
GO:0140664 ATP-dependent DNA damage sensor activity
Biological Process
GO:0000018 regulation of DNA recombination
GO:0006281 DNA repair
GO:0006298 mismatch repair
GO:0006974 DNA damage response
Cellular Component
GO:0005829 cytosol
GO:0032300 mismatch repair complex
GO:1990710 MutS complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7ou2, PDBe:7ou2, PDBj:7ou2
PDBsum7ou2
PubMed35013597
UniProtP23909|MUTS_ECOLI DNA mismatch repair protein MutS (Gene Name=mutS)

[Back to BioLiP]