Structure of PDB 7oqr Chain B

Receptor sequence
>7oqrB (length=271) Species: 5693 (Trypanosoma cruzi) [Search protein sequence]
KVTEAPPFDVNSLRRDIEEILSEDMSKGPLFVRLAWHEAGSWDCRKKDGS
PNSASMRFHPECSYAGNKGLDKGRNALESLKKKYPKISYADLWSFAAVVS
IEAMGGPEIPWRWGRVDAKDGSVCGPDGRLPDASRMQDHVRDVFSRLGFN
DEETVALIGAHTCGECHLENTGYVGPFTHDKYGFDNSFFTELFGNEWMLN
PNVKKMQFMDKTTNRLMMLPADVSILLDDKYRSIAKKYADDNDYFCNAFS
KAYQKLLEVGTTDLKSLPAES
3D structure
PDB7oqr Crystal structure of Trypanosoma cruzi heme peroxidase and characterization of its substrate specificity and compound I intermediate.
ChainB
Resolution1.76 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.11.1.5: cytochrome-c peroxidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HEM B P85 W92 P187 A189 L213 A216 H217 G220 E221 C222 H223 N226 T227 L275 Y309 P29 W36 P131 A133 L157 A160 H161 G164 E165 C166 H167 N170 T171 L219 Y253
BS02 OXY B R89 W92 H93 R33 W36 H37
Gene Ontology
Molecular Function
GO:0004601 peroxidase activity
GO:0016688 L-ascorbate peroxidase activity
GO:0020037 heme binding
GO:0046872 metal ion binding
Biological Process
GO:0000302 response to reactive oxygen species
GO:0006979 response to oxidative stress
GO:0034599 cellular response to oxidative stress
GO:0042744 hydrogen peroxide catabolic process
GO:0098869 cellular oxidant detoxification
Cellular Component
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7oqr, PDBe:7oqr, PDBj:7oqr
PDBsum7oqr
PubMed35772495
UniProtQ8I1N3

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