Structure of PDB 7opr Chain B

Receptor sequence
>7oprB (length=208) Species: 9606 (Homo sapiens) [Search protein sequence]
HMSFLTEEEQEAIMKVLQRDAALKRAEEERGDYDYLIKFLALGDSGVGKT
SVLYQYTDGKFNSKFITTVGIDFREKRVVYRAGRGQRIHLQLWDTAGLER
FRSLTTAFFRDAMGFLLLFDLTNEQSFLNVRNWISQLQMHAYCENPDIVL
CGNKSDLEDQRVVKEEEAIALAEKYGIPYFETSAANGTNISQAIEMLLDL
IMKRMERS
3D structure
PDB7opr Identification of the first structurally validated covalent ligands of the small GTPase RAB27A.
ChainB
Resolution2.32 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GNP B S18 G19 G21 K22 T23 S24 F34 S36 F38 T40 T41 G77 N133 K134 D136 L137 S163 A164 S45 G46 G48 K49 T50 S51 F61 S63 F65 T67 T68 G97 N153 K154 D156 L157 S183 A184
BS02 MG B T23 T41 T50 T68
BS03 05Y B K11 D91 M93 Y122 C123 M185 K38 D111 M113 Y142 C143 M205
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
GO:0031267 small GTPase binding
Biological Process
GO:0006886 intracellular protein transport

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Molecular Function
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Biological Process
External links
PDB RCSB:7opr, PDBe:7opr, PDBj:7opr
PDBsum7opr
PubMed35308027
UniProtP51159|RB27A_HUMAN Ras-related protein Rab-27A (Gene Name=RAB27A);
Q9HCH5

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