Structure of PDB 7opq Chain B

Receptor sequence
>7opqB (length=204) Species: 9606 (Homo sapiens) [Search protein sequence]
SFLTEEEQEAIMKVLQRDAALKRAEEEDYDYLIKFLALGDSGVGKTSVLY
QYTDGKFNSKFITTVGIDFREKRVVYRASRGQRIHLQLWDTAGLERFRSL
TTAFFRDAMGFLLLFDLTNEQSFLNVRNWISQLQMHAYSENPDIVLCGNK
SDLEDQRVVKEEEAIALAEKYGIPYFETSAANGTNISQAIEMLLDLIMKR
MERC
3D structure
PDB7opq Identification of the first structurally validated covalent ligands of the small GTPase RAB27A.
ChainB
Resolution2.23 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 06D B K10 M92 Y121 M184 C187 K34 M109 Y138 M201 C204
BS02 GNP B S17 G18 G20 K21 T22 S23 F33 S35 F37 T39 T40 G76 N132 K133 D135 L136 S162 A163 S41 G42 G44 K45 T46 S47 F57 S59 F61 T63 T64 G93 N149 K150 D152 L153 S179 A180
BS03 MG B T22 T40 T46 T64
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
GO:0031267 small GTPase binding
Biological Process
GO:0006886 intracellular protein transport

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Molecular Function
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Biological Process
External links
PDB RCSB:7opq, PDBe:7opq, PDBj:7opq
PDBsum7opq
PubMed35308027
UniProtP51159|RB27A_HUMAN Ras-related protein Rab-27A (Gene Name=RAB27A);
Q9HCH5

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