Structure of PDB 7oma Chain B

Receptor sequence

>7omaB (length=628) Species: 83810 (Thosea asigna virus)

RLSLEAMLAERAMVARQDLAGLKRKLAGADRVLAPQSPEQCGRESAQAQA
RSVTSELKSAVKEAQGLEHQTLDFLEQLGEYPVCGILHGDHPVHPSGTHN
NNGKVSVKRQFAAGSDALTCAFRFEDSDLVRETALKTTYTDGTWAGFVQR
LKMQTTRKCVQEKVSRKLLKQLFPYDPQKLVDVSGELSELVLGIKTNAIA
SAGPPYWRTKRDALPDMLDCVLPLLYDHIVRKDLTTLRNKHPELFLAECK
NKTDRYEVESLGEKTRPYFSHPFHLSALVSVLSQSFSGALKIMTEDSTSF
NAYGFSWTNGGAEDLAIWARQAGEAGKKPPRIACYGDDTDIYYRKDGKLY
RICPDFKQMDGSVDATTIEAVVDYVVDAHVKQYPTARQFWEEVGKLWVEM
ATQSPFLIDGTKVYRKMQKDGLMTGVVGTTLFDTVKSALAYNDWADQLMF
GSLNLLEEKYAIEFFKNKHGLVIKEGTWKPALVNEDPGFGELWTEQKFLG
LQLKVVRRENEKVYVPNLPFEDWLTMWVTPRSETETMRERTLFDRARGLL
VTGAVFDERARGLMGAVINSTAPEVVCMRVQISDGYPSYDWVVSLYSRDH
PCDMPRVFPEAATLIASYRKQVMDTRVV

3D structure

• PDB: 7oma Snapshots of a Non-Canonical RdRP in Action.
• Chain: B
• Resolution: 3.1 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	B	K266 R280 Y349 D351 D374 T438 T443 D447 L513 M540 R545 D563 R564 G567 L568 T571	K252 R266 Y335 D337 D360 T424 T429 D433 L499 M526 R531 D544 R545 G548 L549 T552
BS02	rna	B	I213 A214 S215 K224 K264 K266 Y282 F283 S294 Y317 G318 S320 T322 Y349 G439 V441 W633	I199 A200 S201 K210 K250 K252 Y268 F269 S280 Y303 G304 S306 T308 Y335 G425 V427 W591
BS03	POP	B	R164 R280 F370 K371 Q372 M373 K488	R150 R266 F356 K357 Q358 M359 K474
BS04	MG	B	D352 D369	D338 D355
BS05	MG	B	D351 D369 F370	D337 D355 F356

External links

• PDB: RCSB:7oma, PDBe:7oma, PDBj:7oma
• PDBsum: 7oma
• PubMed: 34203380
• UniProt: Q6A562