Structure of PDB 7oiw Chain B

Receptor sequence

>7oiwB (length=327) Species: 158878 (Staphylococcus aureus subsp. aureus Mu50)

PYSADEVLHKAKSYLSADEYEYVLKSYHIAYEAHKGQFRKNGLPYIMHPI
QVAGILTEMRLDGPTIVAGFLHDVIEDTPYTFEDVKEMFNEEVARIVDGV
TKLKENHRKLFIAIAKDVRVILVKLADRLHNMRTLKAMPREKQIRISRET
LEIYAPLAHHLGINTIKWELEDTALRYIDNVQYFRIVNLMKKKRSEREAY
IETAIDRIRTEMDRMNIEGDINGRPKHIYSIYRKMMKQKKQFDQIFDLLA
IRVIVNSINDCYAILGLVHTLWKPMPGRFKDYIAMPKQNLYQSLHTTVVG
PNGDPLEIQIRTFDMHEIAEHGVAAHW

3D structure

• PDB: 7oiw Structure of S. aureus Rel catalytic domains in complex with pppGpp
• Chain: B
• Resolution: 2.63 Å

Enzymatic activity

• Enzyme Commision number: 2.7.6.5: GTP diphosphokinase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	0O2	B	R51 K52 N53 K148 D151 R152 N155 T158 M162 K166	R39 K40 N41 K124 D127 R128 N131 T134 M138 K142
BS02	0O2	B	N188 R248 K250 H251 S254 K258 R302 K304 K311 N313 Y315 H319 Q333 A343	N164 R224 K226 H227 S230 K234 R278 K280 K287 N289 Y291 H295 Q309 A319
BS03	MN	B	H60 H84 D85 D151	H48 H72 D73 D127

Gene Ontology

Biological Process

• GO:0015969 guanosine tetraphosphate metabolic process

External links

• PDB: RCSB:7oiw, PDBe:7oiw, PDBj:7oiw
• PDBsum: 7oiw
• UniProt: Q931Q4|RELA_STAAM GTP pyrophosphokinase (Gene Name=relA)