Structure of PDB 7ogj Chain B

Receptor sequence
>7ogjB (length=212) Species: 9606 (Homo sapiens) [Search protein sequence]
VKPEEMDWSELYPEFFAPLTQAQAQVEFADIGCGYGGLLVELSPLFPDTL
ILGLEIRVKVSDYVQDRIRALRAAPAGGFQNIACLRSNAMKHLPNFFYKG
QLTKMFFLFPDPHFKRTKHKWRIISPTLLAEYAYVLRVGGLVYTITDVLE
LHDWMCTHFEEHPLFERVPLEDLSEDPVVGHLGTSTEEGKKVLRNGGKNF
PAIFRRIQDPVL
3D structure
PDB7ogj Crystal structure of human METTL1 in complex with SAH
ChainB
Resolution1.59 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.-
2.1.1.33: tRNA (guanine(46)-N(7))-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAH B G54 C55 G56 E77 I78 R79 S109 N110 A111 L130 F131 D133 H135 T208 E210 G32 C33 G34 E55 I56 R57 S87 N88 A89 L108 F109 D111 H113 T186 E188
Gene Ontology
Molecular Function
GO:0008176 tRNA (guanine(46)-N7)-methyltransferase activity
Biological Process
GO:0006400 tRNA modification

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Molecular Function
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Biological Process
External links
PDB RCSB:7ogj, PDBe:7ogj, PDBj:7ogj
PDBsum7ogj
PubMed
UniProtQ9UBP6|TRMB_HUMAN tRNA (guanine-N(7)-)-methyltransferase (Gene Name=METTL1)

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