Structure of PDB 7o75 Chain B

Receptor sequence
>7o75B (length=1180) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence]
FEDESAPITAEDSWAVISAFFREKGLVSQQLDSFNQFVDYTLQDIICEDS
TLILEQLAQHTTESDNISRKYEISFGKIYVTKPMVNESDGVTHALYPQEA
RLRNLTYSSGLFVDVKKRTYEAIDVPGRELKYELIAEESEGKVFIGRLPI
MLRSKNCYLSEATESDLYKLKECPFDMGGYFIINGSEKVLIAQERSAGNI
VQVFKKAAPSPISHVAEIRSALEKGSRFISTLQVKLYGREGSSARTIKAT
LPYIKQDIPIVIIFRALGIIPDGEILEHICYDVNDWQMLEMLKPCVEDGF
VIQDRETALDFIGRRGTALGIKKEKRIQYAKDILQKEFLPHITQLEGFES
RKAFFLGYMINRLLLCALDRKDQDDRDHFGKKRLDLAGPLLAQLFKTLFK
KLTKDIFRYMQRTVEEAHDFNMKLAINAKTITSGLKYALATGNWGERAGV
SQVLNRYTYSSTLSHLRRTNTPIGKLAKPRQLHNTHWGLVCPAETPEGQA
CGLVKNLSLMSCISVGTDPMPIITFLSEWGMEPLEDYVPHQSPDATRVFV
NGVWHGVHRNPARLMETLRTLRRKGDINPEVSMIRDIREKELKIFTDAGR
VYRPLFIVEDDESLGHKELKVRKGHIAKLMATEYQDIDVEEYTWSSLLNE
GLVEYIDAEEEESILIAMQPEDLEPAEDVDPAKRIRVSHHATTFTHCEIH
PSMILGVAASIIPFPDHNQSPRNTYQSAMGKQAMGVFLTNYNVRMDTMAN
ILYYPQKPLGTTRAMEYLKFRELPAGQNAIVAIACYSGYNQEDSMIMNQS
SIDRGLFRSLFFRSYMDQEKKYGMSITETFEKPQRTNTLRMKHGTYDKLD
DDGLIAPGVRVSGEDVIIGKTTPISPDEEELGQRTAYHSKRDASTPLRST
ENGIVDQVLVTTNQDGLKFVKVRVRTTKIPQIGDKFASRHGQKGTIGITY
RREDMPFTAEGIVPDLIINPHAIPSRMTVAHLIECLLSKVAALSGNEGDA
SPFTDITVEGISKLLREHGYQSRGFEVMYNGHTGKKLMAQIFFGPTYYQR
LRHMVDDKIHARARGPMQVLTRQPVEGRSRDGGLRFGEMERDCMIAHGAA
SFLKERLMEASDAFRVHICGICGLMTVIAKLNHNQFECKGCDNKIDIYQI
HIPYAAKLLFQELMAMNITPRLYTDRSRDF
3D structure
PDB7o75 Structure of RNA polymerase II pre-initiation complex at 2.9 angstrom defines initial DNA opening.
ChainB
Resolution3.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B C1163 C1185 C1119 C1141
Gene Ontology
Molecular Function
GO:0001055 RNA polymerase II activity
GO:0003677 DNA binding
GO:0003729 mRNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0003968 RNA-dependent RNA polymerase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016779 nucleotidyltransferase activity
GO:0032549 ribonucleoside binding
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0001172 RNA-templated transcription
GO:0006351 DNA-templated transcription
GO:0006366 transcription by RNA polymerase II
GO:0006367 transcription initiation at RNA polymerase II promoter
GO:0006368 transcription elongation by RNA polymerase II
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005665 RNA polymerase II, core complex
GO:0005739 mitochondrion
GO:0010494 cytoplasmic stress granule

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7o75, PDBe:7o75, PDBj:7o75
PDBsum7o75
PubMed34133942
UniProtP08518|RPB2_YEAST DNA-directed RNA polymerase II subunit RPB2 (Gene Name=RPB2)

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