Structure of PDB 7nyd Chain B

Receptor sequence

>7nydB (length=718) Species: 9606 (Homo sapiens)

CFCDHYAWTQWTSCSKTCNSGTQSRHRQIVVDKYYQENFCEQICSKQETR
ECNWQRCPINCLLGDFGPWSDCDPCIEKQSKVRSVLRPSQFGGQPCTAPL
VAFQPCIPSKLCKIEEADCKNKFRCDSGRCIARKLECNGENDCGDNSDER
DCGRTKAVCTRKYNPIPSVQLMGNGFHFLAGEPRGEVLDNSFTGGICKTV
KSSRTSNPYRVPANLENVGFEVQTAEDDLKTDFYKDLTSLGHNENQQGSF
SSRSENINHNSAFKQAIQASHKKDSSFIRIHKVMKVLNFTTKAKDLHLSD
VFLKALNHLPLEYNSALYSRIFDDFGTHYFTSGSLGGVYDLLYQFSSEEL
KNSGLTEEEAKHCVRIETTKVEHRCTTNKLSEKHEGSFIQGAEKSISLIR
GGRSEYGAALAWEKGSSGLEEKTFSEWLESVKENPAVIDFELAPIVDLVR
NIPCAVTKRNNLRKALQEYAAKFDPCQCAPCPNNGRPTLSGTECLCVCQS
GTYGENCEKQSPDYKSNAVDGQWGCWSSWSTCDATYKRSRTRECNNPAPQ
RGGKRCEGEKRQEEDCTFSIMENNGQPCINDDEEMKEVDLPEIEADSGCP
QPVPPENGFIRNEKQLYLVGEDVEISCLTGFETVGYQYFRCLPDGTWRQG
DVECQRTECIKPVVQEVLTITPFQRLYRIGESIELTCPKGFVVAGPSRYT
CQGNSWTPPISNSLTCEK

3D structure

• PDB: 7nyd Structural basis of soluble membrane attack complex packaging for clearance.
• Chain: B
• Resolution: 3.27 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	FUC	B	T17 C18	T17 C18

Gene Ontology

Molecular Function

• GO:0005515 protein binding

Biological Process

• GO:0001701 in utero embryonic development
• GO:0006955 immune response
• GO:0006956 complement activation
• GO:0006958 complement activation, classical pathway
• GO:0031640 killing of cells of another organism
• GO:0045087 innate immune response
• GO:0050778 positive regulation of immune response

Cellular Component

• GO:0005576 extracellular region
• GO:0005579 membrane attack complex
• GO:0005615 extracellular space
• GO:0005886 plasma membrane
• GO:0070062 extracellular exosome

External links

• PDB: RCSB:7nyd, PDBe:7nyd, PDBj:7nyd
• PDBsum: 7nyd
• PubMed: 34667172
• UniProt: P13671|CO6_HUMAN Complement component C6 (Gene Name=C6)