BioLiP

Site
#

Ligand

Ligand
chain

Binding residues on receptor
(original residue number in PDB)

Binding residues on receptor
(residue number reindexed from 1)

Binding affinity

S134 M135 D137 D138 A342

S132 M133 D135 D136 A340

BS03

E169 N224 D226 P228 E229

E167 N222 D224 P226 E227

	Molecular Function
GO:0000287	magnesium ion binding
GO:0001618	virus receptor activity
GO:0001968	fibronectin binding
GO:0002020	protease binding
GO:0003779	actin binding
GO:0005178	integrin binding
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0015026	coreceptor activity
GO:0019901	protein kinase binding
GO:0019960	C-X3-C chemokine binding
GO:0038023	signaling receptor activity
GO:0043236	laminin binding
GO:0044877	protein-containing complex binding
GO:0045296	cadherin binding
GO:0046872	metal ion binding
GO:0046982	protein heterodimerization activity
GO:0050839	cell adhesion molecule binding
GO:0098639	collagen binding involved in cell-matrix adhesion
GO:0098640	integrin binding involved in cell-matrix adhesion
GO:1990782	protein tyrosine kinase binding

	Biological Process
GO:0000082	G1/S transition of mitotic cell cycle
GO:0000132	establishment of mitotic spindle orientation
GO:0001525	angiogenesis
GO:0001701	in utero embryonic development
GO:0002042	cell migration involved in sprouting angiogenesis
GO:0002052	positive regulation of neuroblast proliferation
GO:0006909	phagocytosis
GO:0006968	cellular defense response
GO:0007155	cell adhesion
GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules
GO:0007159	leukocyte cell-cell adhesion
GO:0007160	cell-matrix adhesion
GO:0007161	calcium-independent cell-matrix adhesion
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0007229	integrin-mediated signaling pathway
GO:0007405	neuroblast proliferation
GO:0007517	muscle organ development
GO:0007520	myoblast fusion
GO:0008283	cell population proliferation
GO:0008354	germ cell migration
GO:0008542	visual learning
GO:0010710	regulation of collagen catabolic process
GO:0010763	positive regulation of fibroblast migration
GO:0014850	response to muscle activity
GO:0016477	cell migration
GO:0021943	formation of radial glial scaffolds
GO:0023035	CD40 signaling pathway
GO:0030030	cell projection organization
GO:0030032	lamellipodium assembly
GO:0030182	neuron differentiation
GO:0030183	B cell differentiation
GO:0030198	extracellular matrix organization
GO:0030335	positive regulation of cell migration
GO:0031175	neuron projection development
GO:0031589	cell-substrate adhesion
GO:0031623	receptor internalization
GO:0033627	cell adhesion mediated by integrin
GO:0033631	cell-cell adhesion mediated by integrin
GO:0034113	heterotypic cell-cell adhesion
GO:0035024	negative regulation of Rho protein signal transduction
GO:0035313	wound healing, spreading of epidermal cells
GO:0035633	maintenance of blood-brain barrier
GO:0043065	positive regulation of apoptotic process
GO:0043149	stress fiber assembly
GO:0043547	positive regulation of GTPase activity
GO:0045214	sarcomere organization
GO:0045445	myoblast differentiation
GO:0045665	negative regulation of neuron differentiation
GO:0045743	positive regulation of fibroblast growth factor receptor signaling pathway
GO:0045766	positive regulation of angiogenesis
GO:0045906	negative regulation of vasoconstriction
GO:0046718	symbiont entry into host cell
GO:0048333	mesodermal cell differentiation
GO:0048626	myoblast fate specification
GO:0048675	axon extension
GO:0048813	dendrite morphogenesis
GO:0050804	modulation of chemical synaptic transmission
GO:0050901	leukocyte tethering or rolling
GO:0051726	regulation of cell cycle
GO:0051897	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO:0051951	positive regulation of glutamate uptake involved in transmission of nerve impulse
GO:0055007	cardiac muscle cell differentiation
GO:0060379	cardiac muscle cell myoblast differentiation
GO:0060912	cardiac cell fate specification
GO:0071404	cellular response to low-density lipoprotein particle stimulus
GO:0071711	basement membrane organization
GO:0090303	positive regulation of wound healing
GO:0098609	cell-cell adhesion
GO:0150003	regulation of spontaneous synaptic transmission
GO:0150103	reactive gliosis
GO:1900748	positive regulation of vascular endothelial growth factor signaling pathway
GO:1901979	regulation of inward rectifier potassium channel activity
GO:1903078	positive regulation of protein localization to plasma membrane
GO:1905806	regulation of synapse pruning
GO:2000811	negative regulation of anoikis

Biological Process

GO:0000082

G1/S transition of mitotic cell cycle

GO:0000132

establishment of mitotic spindle orientation

GO:0001525

angiogenesis

GO:0001701

in utero embryonic development

GO:0002042

cell migration involved in sprouting angiogenesis

GO:0002052

positive regulation of neuroblast proliferation

GO:0006909

phagocytosis

GO:0006968

cellular defense response

GO:0007155

cell adhesion

GO:0007156

homophilic cell adhesion via plasma membrane adhesion molecules

GO:0007159

leukocyte cell-cell adhesion

GO:0007160

cell-matrix adhesion

GO:0007161

calcium-independent cell-matrix adhesion

GO:0007179

transforming growth factor beta receptor signaling pathway

GO:0007229

integrin-mediated signaling pathway

GO:0007405

neuroblast proliferation

GO:0007517

muscle organ development

GO:0007520

myoblast fusion

GO:0008283

cell population proliferation

GO:0008354

germ cell migration

GO:0008542

visual learning

GO:0010710

regulation of collagen catabolic process

GO:0010763

positive regulation of fibroblast migration

GO:0014850

response to muscle activity

GO:0016477

cell migration

GO:0021943

formation of radial glial scaffolds

GO:0023035

CD40 signaling pathway

GO:0030030

cell projection organization

GO:0030032

lamellipodium assembly

GO:0030182

neuron differentiation

GO:0030183

B cell differentiation

GO:0030198

extracellular matrix organization

GO:0030335

positive regulation of cell migration

GO:0031175

neuron projection development

GO:0031589

cell-substrate adhesion

GO:0031623

receptor internalization

GO:0033627

cell adhesion mediated by integrin

GO:0033631

cell-cell adhesion mediated by integrin

GO:0034113

heterotypic cell-cell adhesion

GO:0035024

negative regulation of Rho protein signal transduction

GO:0035313

wound healing, spreading of epidermal cells

GO:0035633

maintenance of blood-brain barrier

GO:0043065

positive regulation of apoptotic process

GO:0043149

stress fiber assembly

GO:0043547

positive regulation of GTPase activity

GO:0045214

sarcomere organization

GO:0045445

myoblast differentiation

GO:0045665

negative regulation of neuron differentiation

GO:0045743

positive regulation of fibroblast growth factor receptor signaling pathway

GO:0045766

positive regulation of angiogenesis

GO:0045906

negative regulation of vasoconstriction

GO:0046718

symbiont entry into host cell

GO:0048333

mesodermal cell differentiation

GO:0048626

myoblast fate specification

GO:0048675

axon extension

GO:0048813

dendrite morphogenesis

GO:0050804

modulation of chemical synaptic transmission

GO:0050901

leukocyte tethering or rolling

GO:0051726

regulation of cell cycle

GO:0051897

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

GO:0051951

positive regulation of glutamate uptake involved in transmission of nerve impulse

GO:0055007

cardiac muscle cell differentiation

GO:0060379

cardiac muscle cell myoblast differentiation

GO:0060912

cardiac cell fate specification

GO:0071404

cellular response to low-density lipoprotein particle stimulus

GO:0071711

basement membrane organization

GO:0090303

positive regulation of wound healing

GO:0098609

cell-cell adhesion

GO:0150003

regulation of spontaneous synaptic transmission

GO:0150103

reactive gliosis

GO:1900748

positive regulation of vascular endothelial growth factor signaling pathway

GO:1901979

regulation of inward rectifier potassium channel activity

GO:1903078

positive regulation of protein localization to plasma membrane

GO:1905806

regulation of synapse pruning

GO:2000811

negative regulation of anoikis

	Cellular Component
GO:0001726	ruffle
GO:0005737	cytoplasm
GO:0005768	endosome
GO:0005886	plasma membrane
GO:0005925	focal adhesion
GO:0008305	integrin complex
GO:0009897	external side of plasma membrane
GO:0009986	cell surface
GO:0010008	endosome membrane
GO:0014704	intercalated disc
GO:0016020	membrane
GO:0030027	lamellipodium
GO:0030175	filopodium
GO:0031410	cytoplasmic vesicle
GO:0031594	neuromuscular junction
GO:0032154	cleavage furrow
GO:0032587	ruffle membrane
GO:0034665	integrin alpha1-beta1 complex
GO:0034666	integrin alpha2-beta1 complex
GO:0034667	integrin alpha3-beta1 complex
GO:0034668	integrin alpha4-beta1 complex
GO:0034674	integrin alpha5-beta1 complex
GO:0034675	integrin alpha6-beta1 complex
GO:0034677	integrin alpha7-beta1 complex
GO:0034678	integrin alpha8-beta1 complex
GO:0034679	integrin alpha9-beta1 complex
GO:0034680	integrin alpha10-beta1 complex
GO:0034681	integrin alpha11-beta1 complex
GO:0034682	integrin alphav-beta1 complex
GO:0035748	myelin sheath abaxonal region
GO:0042383	sarcolemma
GO:0042470	melanosome
GO:0042995	cell projection
GO:0043197	dendritic spine
GO:0043235	receptor complex
GO:0045121	membrane raft
GO:0045202	synapse
GO:0048471	perinuclear region of cytoplasm
GO:0055037	recycling endosome
GO:0070062	extracellular exosome
GO:0070161	anchoring junction
GO:0097060	synaptic membrane
GO:0097386	glial cell projection
GO:0098685	Schaffer collateral - CA1 synapse
GO:0098978	glutamatergic synapse
GO:0150053	cerebellar climbing fiber to Purkinje cell synapse

Cellular Component

ruffle

cytoplasm

endosome

plasma membrane

focal adhesion