Structure of PDB 7nwb Chain B

Receptor sequence
>7nwbB (length=364) Species: 9606 (Homo sapiens) [Search protein sequence]
VGTFKAKDLIVTPATILKEKPDPNNLVFGTVFTDHMLTVEWSSEFGWEKP
HIKPLQNLSLHPGSSALHYAVELFEGLKAFRGVDNKIRLFQPNLNMDRMY
RSAVRATLPVFDKEELLECIQQLVKLDQEWVPYSTSASLYIRPTFIGTEP
SLGVKKPTKALLFVLLSPVGPYFSSTFNPVSLWANPKYVRAWKGGTGDCK
MGGNYGSSLFAQCEAVDNGCQQVLWLYGEDHQITEVGTMNLFLYWINEDG
EEELATPPLDGIILPGVTRRCILDLAHQWGEFKVSERYLTMDDLTTALEG
NRVREMFGSGTACVVCPVSDILYKGETIHIPTMENGPKLASRILSKLTDI
QYGREERDWTIVLS
3D structure
PDB7nwb BAY-069, a Novel (Trifluoromethyl)pyrimidinedione-Based BCAT1/2 Inhibitor and Chemical Probe.
ChainB
Resolution2.64 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.6.1.42: branched-chain-amino-acid transaminase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 UTK B Y90 G174 V175 Y69 G153 V154
BS02 UTK B F49 F95 Y161 Y193 Q234 Q244 A334 F28 F74 Y140 Y172 Q212 Q222 A312
BS03 PLP B R119 R212 K222 Y227 E257 T260 L286 G288 V289 T290 T333 R98 R190 K200 Y205 E235 T238 L264 G266 V267 T268 T311
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004084 branched-chain-amino-acid transaminase activity
GO:0008483 transaminase activity
GO:0052654 L-leucine-2-oxoglutarate transaminase activity
GO:0052655 L-valine-2-oxoglutarate transaminase activity
GO:0052656 L-isoleucine-2-oxoglutarate transaminase activity
Biological Process
GO:0000082 G1/S transition of mitotic cell cycle
GO:0006629 lipid metabolic process
GO:0008652 amino acid biosynthetic process
GO:0009081 branched-chain amino acid metabolic process
GO:0009082 branched-chain amino acid biosynthetic process
GO:0009098 L-leucine biosynthetic process
GO:0009099 L-valine biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7nwb, PDBe:7nwb, PDBj:7nwb
PDBsum7nwb
PubMed36261130
UniProtP54687|BCAT1_HUMAN Branched-chain-amino-acid aminotransferase, cytosolic (Gene Name=BCAT1)

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