Structure of PDB 7ntr Chain B

Receptor sequence
>7ntrB (length=361) Species: 9606 (Homo sapiens) [Search protein sequence]
VGTFKAKDLIVTPATILKEKPDPNNLVFGTVFTDHMLTVEWSSEFGWEKP
HIKPLQNLSLHPGSSALHYAVELFEGLKAFRGVDNKIRLFQPNLNMDRMY
RSAVRATLPVFDKEELLECIQQLVKLDQEWVPYSTSASLYIRPTFIGTEP
SLGVKKPTKALLFVLLSPVGPYFFNPVSLWANPKYVRAWKGGTGDCKMGG
NYGSSLFAQCEAVDNGCQQVLWLYGEDHQITEVGTMNLFLYWINEDGEEE
LATPPLDGIILPGVTRRCILDLAHQWGEFKVSERYLTMDDLTTALEGNRV
REMFGSGTACVVCPVSDILYKGETIHIPTMENGPKLASRILSKLTDIQYG
REERDWTIVLS
3D structure
PDB7ntr BAY-069, a Novel (Trifluoromethyl)pyrimidinedione-Based BCAT1/2 Inhibitor and Chemical Probe.
ChainB
Resolution2.23 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.6.1.42: branched-chain-amino-acid transaminase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HCI B F49 Y193 T260 G332 T333 A334 F28 Y172 T235 G307 T308 A309
BS02 PLP B R119 R212 K222 Y227 E257 T260 M261 N262 L286 G288 V289 T290 G332 T333 R98 R187 K197 Y202 E232 T235 M236 N237 L261 G263 V264 T265 G307 T308
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004084 branched-chain-amino-acid transaminase activity
GO:0008483 transaminase activity
GO:0052654 L-leucine-2-oxoglutarate transaminase activity
GO:0052655 L-valine-2-oxoglutarate transaminase activity
GO:0052656 L-isoleucine-2-oxoglutarate transaminase activity
Biological Process
GO:0000082 G1/S transition of mitotic cell cycle
GO:0006629 lipid metabolic process
GO:0008652 amino acid biosynthetic process
GO:0009081 branched-chain amino acid metabolic process
GO:0009082 branched-chain amino acid biosynthetic process
GO:0009098 L-leucine biosynthetic process
GO:0009099 L-valine biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7ntr, PDBe:7ntr, PDBj:7ntr
PDBsum7ntr
PubMed36261130
UniProtP54687|BCAT1_HUMAN Branched-chain-amino-acid aminotransferase, cytosolic (Gene Name=BCAT1)

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