Structure of PDB 7nt4 Chain B

Receptor sequence
>7nt4B (length=313) Species: 2697049 (Severe acute respiratory syndrome coronavirus 2) [Search protein sequence]
RTIKVFTTVDNINLHTQVVDMSMTYGQQFGPTYLDGADVTKIKPHNSHEG
KTFYVLPNDDTLRVEAFEYYHTTDPSFLGRYMSALNHTKKWKYPQVNGLT
SIKWADNNCYLATALLTLQQIELKFNPPALQDAYYRARAGEAANFCALIL
AYCNKTVGELGDVRETMSYLFQHANLDSCKRVLNVVCKTCGQQQTTLKGV
EAVMYMGTLSYEQFKKGVQIPCTCGKQATKYLVQQESPFVMMSAPPAQYE
LKHGTFTCASEYTGNYQCGHYKHITSKETLYCIDGALLTKSSEYKGPITD
VFYKENSYTTTIK
3D structure
PDB7nt4 Acriflavine, a clinically approved drug, inhibits SARS-CoV-2 and other betacoronaviruses.
ChainB
Resolution2.68 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
2.7.7.50: mRNA guanylyltransferase.
3.1.13.-
3.4.19.12: ubiquitinyl hydrolase 1.
3.4.22.-
3.4.22.69: SARS coronavirus main proteinase.
3.6.4.12: DNA helicase.
3.6.4.13: RNA helicase.
4.6.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PRL B W107 H273 W104 H270
BS02 PRL B G164 D165 Y265 Y269 G161 D162 Y262 Y266
BS03 PRL B P248 P249 Y265 Y274 P245 P246 Y262 Y271
BS04 ZN B C190 C193 C225 C227 C187 C190 C222 C224
Gene Ontology
Molecular Function
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:7nt4, PDBe:7nt4, PDBj:7nt4
PDBsum7nt4
PubMed35021060
UniProtP0DTD1|R1AB_SARS2 Replicase polyprotein 1ab (Gene Name=rep)

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