Structure of PDB 7njm Chain B

Receptor sequence

>7njmB (length=504) Species: 246196 (Mycolicibacterium smegmatis MC2 155)

TISAADIEGAIEDYVSSFEEIGTVIDAGDGIAHVEGLPSVMTQELLEFPG
GVLGVALNLDEHSVGAVILGEFEKIEEGQQVKRTGEVLSVPVGDAFLGRV
VNPLGQPIDGQGDIAAETRRALELQAPSVVQRQSVSEPLQTGIKAIDAMT
PIGRGQRQLIIGDRKTGKTAVCVDTILNQREAWLTGDPKQQVRCVYVAIG
QKGTTIASVKRALEEGGAMEYTTIVAAPASDAAGFKWLAPYTGSAIGQHW
MYNGKHVLIVFDDLSKQADAYRAISLLLRRPPGREAFPGDVFYLHSRLLE
RCAKLSDELGGGSMTGLPIIETKANDISAFIPTNVISITDGQCFLESDLF
NQGVRPAINVGVSVSRVGGAAQIKAMKEVAGSLRLDLSQYRELEAFDAAS
KAQLDRGARLVELLKQPQYSPLAVEEQVVAIFLGTQGHLDSVPVEDVQRF
ESELLEHVKASHSDIFDGIRETKKLSEEAEEKLVSVINEFKKGFQASDGS
SVVV

3D structure

• PDB: 7njm Structure of the ATP synthase from Mycobacterium smegmatis provides targets for treating tuberculosis.
• Chain: B
• Resolution: 2.84 Å

Enzymatic activity

• Enzyme Commision number: 7.1.2.2: H(+)-transporting two-sector ATPase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ATP	B	K175 T176 G177 K178 T179 A180 F360 R365 Q435	K165 T166 G167 K168 T169 A170 F350 R355 Q418
BS02	ATP	B	S347 R376	S337 R366

Gene Ontology

Molecular Function

• GO:0005524 ATP binding
• GO:0032559 adenyl ribonucleotide binding
• GO:0043531 ADP binding
• GO:0046933 proton-transporting ATP synthase activity, rotational mechanism
• GO:0046961 proton-transporting ATPase activity, rotational mechanism

Biological Process

• GO:0006754 ATP biosynthetic process
• GO:0015986 proton motive force-driven ATP synthesis
• GO:0046034 ATP metabolic process
• GO:1902600 proton transmembrane transport

Cellular Component

• GO:0005886 plasma membrane
• GO:0045259 proton-transporting ATP synthase complex
• GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1)

External links

• PDB: RCSB:7njm, PDBe:7njm, PDBj:7njm
• PDBsum: 7njm
• PubMed: 34782468
• UniProt: A0R202|ATPA_MYCS2 ATP synthase subunit alpha (Gene Name=atpA)