BioLiP

>7ni5B (length=2790) Species: 9606 (Homo sapiens) [Search protein sequence]

LVLNDLLICCRQLEHDRATERKKEVEKFKRLIRDPETIKHLDRHSDSKQG
KYLNWDAVFRFLQKYIQKETECLRIASTQASRQKKMQEISSLVKYFIKCA
NRRAPRLKCQELLNYIMDTVKDSSNGAIYGADCSNILLKDILSVRKYWCE
ISQQQWLELFSVYFRLYLKPSQDVHRVLVARIIHAVTKGCCSQTDGLNSK
FLDFFSKAIQCARQEKSSSGLNHILAALTIFLKTLAVNFRIRVCELGDEI
LPTLLYIWTQHRLNDSLKEVIIELFQLQIYIHHPKGAKTQEKGAYESTKW
RSILYNLYDLLVNEISHIGSRGKYSSGFRNIAVKENLIELMADICHQVFE
LGWEVIKDHLQKSQNDFDLVPWLQIATQLISKYPASLPNCELSPLLMILS
QLLPQQRHGERTPYVLRCLTEVALCQDKRSNLESSQKSDLLKLWNKIWCI
TFRGISSEQIQAENFGLLGAIIQGSLVEVDREFWKLFTGSACRPSCPAVC
CLTLALTTSIVPGTFSLKESIMKWLLFYQEVPPILHSNFPHLVLEKILVS
LTMKNCKAAMNFFQSVPECEHHQKDKEELSFSEVEELFLQTTFDKMDFLT
SSIGFSVHQNLKESLDRCLLGLSEQLLNNYSSEITNSETLVRCSRLLVGV
LGCYCYMGVIAEEEAYKSELFQKAKSLMQCAGESITLFKNKTNEEFRIGS
LRNMMQLCTRCLSNCTKKSPNKIASGFFLRLLTSKLMNDIADICKSLASF
IKKIGAINPLAEEYLSKQDLLFLDMLKFLCLCVTTAQTNTVSFRAADIRR
KLLMLIDSSTLEPTKSLHLHMYLMLLKELPGEEYPLPMEDVLELLKPLSN
VCSLYRRDQDVCKTILNHVLHVVKNLGQSNMDSENTRDAQGQFLTVIGAF
WHLTKERKYIFSVRMALVNCLKTLLEADPYSKWAILNVMGKDFPVNEVFT
QFLADNHHQVRMLAAESINRLFQDTLLKALPLKLQQTAFENAYLKAQEGM
REMSHSAENPETLDEIYNRKSVLLTLIAVVLSCSPICEKQALFALCKSVK
ENGLEPHLVKKVLEKVSETFGYRRLEDFMASHLDYLVLEWLNLQDTEYNL
SSFPFILLNYTNIEDFYRSCYKVLIPHLVIRSHFDEVKSIANQIQEDWKS
LLTDCFPKILVNILPYFAYEGTRDSGMAQQRETATKVYDMLKSENLLGKQ
IDHLFISNLPEIVVELLMTLHEPDLDPAPNPPHFPSHVIKATFAYISNCI
LEILSKSPDSYQKILLAICEQAAETNNVYKKHRILKIYHLFVSLLLKDIK
SGLGGAWAFVLRDVIYTLIHYINQRPSCIMDVSLRSFSLCCDLLSQVCQT
AVTYCKDALENHLHVIVGTLIPLVYEQVEVQKQVLDLLKYLVIDNKDNEN
LYITIKLLDPFPDHVVFKDLRITQQKIKYSRGPFSLLEEINHFLSVSVYD
ALPLTRLEGLKDLRRQLELHKDQMVDIMRASQDNPQDGIMVKLVVNLLQL
SKMAINHTGEKEVLEAVGSCLGEVGPIDFSTIAIQHSKDASYTKALKLFE
DKELQWTFIMLTYLNNTLVEDCVKVRSAAVTCLKNILATKTGHSFWEIYK
MTTDPMLAYLQPFRTSRKKFLEVPRFDKENPFEGLDDINLWIPLSENHDI
WIKTLTCAFLDSGGTKCEILQLLKPMCEVKTDFCQTVLPYLIHDILLQDT
NESWRNLLSTHVQGFFTSCLRHHFFRCCLDKKSQRTMLAVVDYMRRQKRP
SSGTIFNDAFWLDLNYLEVAKVAQSCAAHFTALLYAEIYADKKSMDDQEK
ISSLSEKSKEETGISLQDLLLEIYRSIGEPDSLYGCGGGKMLQPITRLRT
YEHEAMWGKALVTYDLETAIPSSTRQAGIIQALQNLGLCHILSVYLKGLD
YENKDWCPELEELHYQAAWRNMQWDHCGTSYHESLYNALQSLRDREFSTF
YESLKYARVKEVEEMCKRSLESVYSLYPTLSRLQAIGELESIGELFSRSV
THRQLSEVYIKWQKHSQLLKDSDFSFQEPIMALRTVILEILMEKEMDNSQ
RECIKDILTKHLVELSILARTFKNTQLPERAIFQIKQYNSVSCGVSEWQL
EEAQVFWAKKEQSLALSILKQMIKKLDASCAANNPSLKLTYTECLRVCGN
WLAETCLENPAVIMQTYLEKAVEVASDELRNGKMKAFLSLARFSDTQYQR
IENYMKSSEFENKQALLKRQRELELDELALRALKEDRKRFLCKAVENYIN
CLLSGEEHDMWVFRLCSLWLENSGVSEVNGMMKRDGMKIPTYKFLPLMYQ
LAARMGTKMMGGLGFHEVLNNLISRISMDHPHHTLFIILALANANRDEFL
TKSQLDEDRTEAANRIICTIRSRRPQMVRSVEALCDAYIILANLDATQWK
TQRKGINIPADQPITKLKNLEDVVVPTMEIKVDHTGEYGNLVTIQSFKAE
FRLAGGVNLPKIIDCVGSDGKERRQLVKGRDDLRQDAVMQQVFQMCNTLL
QRNTETRKRKLTICTYKVVPLSQRSGVLEWCTGTVPIGEFLVNNEDGAHK
RYRPNDFSAFQCQKKMMEVQKKSFEEKYEVFMDVCQNFQPVFRYFCMEKF
LDPAIWFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHID
LGVAFEQGKILPTPETVPFRLTRDIVDGMGITGVEGVFRRCCEKTMEVMR
NSQETLLTIVEVLLYDPLFDWTMNPLKALYLQQQSFNKVAERVLMRLQEK
LKGVEEGTVLSVGGQVNLLIQQAIDPKNLSRLFPGWKAWV

Site
#

Ligand

Ligand
chain

Binding residues on receptor
(original residue number in PDB)

Binding residues on receptor
(residue number reindexed from 1)

Binding affinity

BS01

UF8

A2693 P2699 Y2755 L2767 W2769 C2770 T2773 P2775

A2454 P2460 Y2516 L2528 W2530 C2531 T2534 P2536

BindingDB: IC50=13nM

Molecular Function

GO:0003677

DNA binding

GO:0004672

protein kinase activity

GO:0004674

protein serine/threonine kinase activity

GO:0004677

DNA-dependent protein kinase activity

protein binding

ATP binding

kinase activity

1-phosphatidylinositol-3-kinase activity

GO:0035979

histone H2AXS139 kinase activity

GO:0042802

identical protein binding

GO:0044024

histone H2AS1 kinase activity

GO:0044877

protein-containing complex binding

GO:0106310

protein serine kinase activity

	Biological Process
GO:0000077	DNA damage checkpoint signaling
GO:0000425	pexophagy
GO:0000723	telomere maintenance
GO:0000724	double-strand break repair via homologous recombination
GO:0000729	DNA double-strand break processing
GO:0001541	ovarian follicle development
GO:0001666	response to hypoxia
GO:0001756	somitogenesis
GO:0002331	pre-B cell allelic exclusion
GO:0002376	immune system process
GO:0006281	DNA repair
GO:0006302	double-strand break repair
GO:0006303	double-strand break repair via nonhomologous end joining
GO:0006338	chromatin remodeling
GO:0006468	protein phosphorylation
GO:0006974	DNA damage response
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0007094	mitotic spindle assembly checkpoint signaling
GO:0007095	mitotic G2 DNA damage checkpoint signaling
GO:0007131	reciprocal meiotic recombination
GO:0007140	male meiotic nuclear division
GO:0007143	female meiotic nuclear division
GO:0007165	signal transduction
GO:0007292	female gamete generation
GO:0007420	brain development
GO:0007507	heart development
GO:0008340	determination of adult lifespan
GO:0008585	female gonad development
GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage
GO:0009791	post-embryonic development
GO:0010212	response to ionizing radiation
GO:0010506	regulation of autophagy
GO:0010628	positive regulation of gene expression
GO:0016310	phosphorylation
GO:0018105	peptidyl-serine phosphorylation
GO:0030335	positive regulation of cell migration
GO:0030889	negative regulation of B cell proliferation
GO:0032210	regulation of telomere maintenance via telomerase
GO:0032212	positive regulation of telomere maintenance via telomerase
GO:0033151	V(D)J recombination
GO:0033554	cellular response to stress
GO:0034614	cellular response to reactive oxygen species
GO:0035264	multicellular organism growth
GO:0036092	phosphatidylinositol-3-phosphate biosynthetic process
GO:0036289	peptidyl-serine autophosphorylation
GO:0042159	lipoprotein catabolic process
GO:0042770	signal transduction in response to DNA damage
GO:0042981	regulation of apoptotic process
GO:0043065	positive regulation of apoptotic process
GO:0043517	positive regulation of DNA damage response, signal transduction by p53 class mediator
GO:0043525	positive regulation of neuron apoptotic process
GO:0045141	meiotic telomere clustering
GO:0045785	positive regulation of cell adhesion
GO:0045944	positive regulation of transcription by RNA polymerase II
GO:0046777	protein autophosphorylation
GO:0048538	thymus development
GO:0048599	oocyte development
GO:0051402	neuron apoptotic process
GO:0051726	regulation of cell cycle
GO:0070192	chromosome organization involved in meiotic cell cycle
GO:0071044	histone mRNA catabolic process
GO:0071300	cellular response to retinoic acid
GO:0071479	cellular response to ionizing radiation
GO:0071480	cellular response to gamma radiation
GO:0071481	cellular response to X-ray
GO:0071500	cellular response to nitrosative stress
GO:0080090	regulation of primary metabolic process
GO:0080135	regulation of cellular response to stress
GO:0090398	cellular senescence
GO:0090399	replicative senescence
GO:0097694	establishment of RNA localization to telomere
GO:0097695	establishment of protein-containing complex localization to telomere
GO:1900034	regulation of cellular response to heat
GO:1901796	regulation of signal transduction by p53 class mediator
GO:1903626	positive regulation of DNA catabolic process
GO:1903978	regulation of microglial cell activation
GO:1904262	negative regulation of TORC1 signaling
GO:1904354	negative regulation of telomere capping
GO:1904358	positive regulation of telomere maintenance via telomere lengthening
GO:1904884	positive regulation of telomerase catalytic core complex assembly
GO:2000785	regulation of autophagosome assembly

Biological Process

GO:0000077

DNA damage checkpoint signaling

GO:0000425

pexophagy

GO:0000723

telomere maintenance

GO:0000724

double-strand break repair via homologous recombination

GO:0000729

DNA double-strand break processing

GO:0001541

ovarian follicle development

GO:0001666

response to hypoxia

GO:0001756

somitogenesis

GO:0002331

pre-B cell allelic exclusion

GO:0002376

immune system process

GO:0006281

DNA repair

GO:0006302

double-strand break repair

GO:0006303

double-strand break repair via nonhomologous end joining

GO:0006338

chromatin remodeling

GO:0006468

protein phosphorylation

GO:0006974

DNA damage response

GO:0006977

DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest

GO:0007094

mitotic spindle assembly checkpoint signaling

GO:0007095

mitotic G2 DNA damage checkpoint signaling

GO:0007131

reciprocal meiotic recombination

GO:0007140

male meiotic nuclear division

GO:0007143

female meiotic nuclear division

GO:0007165

signal transduction

GO:0007292

female gamete generation

GO:0007420

brain development

GO:0007507

heart development

GO:0008340

determination of adult lifespan

GO:0008585

female gonad development

GO:0008630

intrinsic apoptotic signaling pathway in response to DNA damage

GO:0009791

post-embryonic development

GO:0010212

response to ionizing radiation

GO:0010506

regulation of autophagy

GO:0010628

positive regulation of gene expression

GO:0016310

phosphorylation

GO:0018105

peptidyl-serine phosphorylation

GO:0030335

positive regulation of cell migration

GO:0030889

negative regulation of B cell proliferation

GO:0032210

regulation of telomere maintenance via telomerase

GO:0032212

positive regulation of telomere maintenance via telomerase

GO:0033151

V(D)J recombination

GO:0033554

cellular response to stress

GO:0034614

cellular response to reactive oxygen species

GO:0035264

multicellular organism growth

GO:0036092

phosphatidylinositol-3-phosphate biosynthetic process

GO:0036289

peptidyl-serine autophosphorylation

GO:0042159

lipoprotein catabolic process

GO:0042770

signal transduction in response to DNA damage

GO:0042981

regulation of apoptotic process

GO:0043065

positive regulation of apoptotic process

GO:0043517

positive regulation of DNA damage response, signal transduction by p53 class mediator

GO:0043525

positive regulation of neuron apoptotic process

GO:0045141

meiotic telomere clustering

GO:0045785

positive regulation of cell adhesion

GO:0045944

positive regulation of transcription by RNA polymerase II

GO:0046777

protein autophosphorylation

GO:0048538

thymus development

GO:0048599

oocyte development

GO:0051402

neuron apoptotic process

GO:0051726

regulation of cell cycle

GO:0070192

chromosome organization involved in meiotic cell cycle

GO:0071044

histone mRNA catabolic process

GO:0071300

cellular response to retinoic acid

GO:0071479

cellular response to ionizing radiation

GO:0071480

cellular response to gamma radiation

GO:0071481

cellular response to X-ray

GO:0071500

cellular response to nitrosative stress

GO:0080090

regulation of primary metabolic process

GO:0080135

regulation of cellular response to stress

GO:0090398

cellular senescence

GO:0090399

replicative senescence

GO:0097694

establishment of RNA localization to telomere

GO:0097695

establishment of protein-containing complex localization to telomere

GO:1900034

regulation of cellular response to heat

GO:1901796

regulation of signal transduction by p53 class mediator

GO:1903626

positive regulation of DNA catabolic process

GO:1903978

regulation of microglial cell activation

GO:1904262

negative regulation of TORC1 signaling

GO:1904354

negative regulation of telomere capping

GO:1904358

positive regulation of telomere maintenance via telomere lengthening

GO:1904884

positive regulation of telomerase catalytic core complex assembly

GO:2000785

regulation of autophagosome assembly

	Cellular Component
GO:0000781	chromosome, telomeric region
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005777	peroxisome
GO:0005782	peroxisomal matrix
GO:0005813	centrosome
GO:0005819	spindle
GO:0005829	cytosol
GO:0005856	cytoskeleton
GO:0031410	cytoplasmic vesicle
GO:0035861	site of double-strand break
GO:0043231	intracellular membrane-bounded organelle
GO:0098850	extrinsic component of synaptic vesicle membrane
GO:1990391	DNA repair complex

Cellular Component

GO:0000781

chromosome, telomeric region

nucleus

nucleoplasm

nucleolus

cytoplasm