Structure of PDB 7nhx Chain B

Receptor sequence
>7nhxB (length=729) Species: 88776 (Influenza A virus (A/Brevig Mission/1/1918(H1N1))) [Search protein sequence]
MDVNPTLLFLKVPAQNAISTTFPYTGDPPYSHGTGTGYTMDTVNRTHQYS
EKGRWTTNTETGAPQLNPIDGPLPEDNEPSGYAQTDCVLEAMAFLEESHP
GIFENSCLETMEVVQQTRVDKLTQGRQTYDWTLNRNQPAATALANTIEVF
RSNGLTANESGRLIDFLKDVMESMDKEEMEITTHFQIGKKKQRLNKRSYL
IRALTLNTMTKDAERGKLKRRAIATPGMQIRGFVYFVETLARSICEKLEQ
SGLPVGGNEKKAKLANVVRKMMTNSQDTELSFTITGDNTKWNENQNPRMF
LAMITYITRNQPEWFRNVLSIAPIMFSNKMARLGKGYMFESKSMKLRTQI
PAEMLASIDLKYFNDSTRKKIEKIRPLLIDGTASLSPGMMMGMFNMLSTV
LGVSILNLGQKRYTKTTYWWDGLQSSDDFALIVNAPNHEGIQAGVDRFYR
TCKLLGINMSKKKSYINRTGTFEFTSFFYRYGFVANFSMELPSFGVSGIN
ESADMSIGVTVIKNNMINNDLGPATAQMALQLFIKDYRYTYRCHRGDTQI
QTRRSFEIKKLWEQTRSKAGLLVSDGGPNLYNIRNLHIPEVCLKWELMDE
DYQGRLCNPLNPFVSHKEIESVNNAVNMEYDAVATTHSWIPKRNRSILNT
SQRGILEDEQMYQKCCNLFEKFFPSSSYRRPVGISSMVEAMVSRARIDAR
IDFESGRIKKEEFAEIMKICSTIEELRRQ
3D structure
PDB7nhx Mapping inhibitory sites on the RNA polymerase of the 1918 pandemic influenza virus using nanobodies.
ChainB
Resolution3.23 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna B R135 N671 R672 S673 L675 N676 R135 N644 R645 S646 L648 N649
BS02 rna B H32 G33 T34 M356 R365 H32 G33 T34 M338 R347
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003723 RNA binding
GO:0003968 RNA-dependent RNA polymerase activity
GO:0034062 5'-3' RNA polymerase activity
Biological Process
GO:0001172 RNA-templated transcription
GO:0006351 DNA-templated transcription
GO:0019083 viral transcription
GO:0039523 symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
GO:0039694 viral RNA genome replication
Cellular Component
GO:0030430 host cell cytoplasm
GO:0042025 host cell nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7nhx, PDBe:7nhx, PDBj:7nhx
PDBsum7nhx
PubMed35017564
UniProtQ3HM40|RDRP_I18A0 RNA-directed RNA polymerase catalytic subunit (Gene Name=PB1)

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