Structure of PDB 7nel Chain B

Receptor sequence
>7nelB (length=245) Species: 9606 (Homo sapiens) [Search protein sequence]
NSLALSLTADQIISALLEAEPPILYSEYDPSRPFSEAYMMGLLTNLADRE
LVHMINWAKKVPGFVDLSLHDQVHLLESAWLEILMIGLVWRSMDHPGKLL
FAPDLLLDREQGKSVEGMVEIFDMLLATSERFREMKLQREEFVCLKAIIL
LNSGVYTFLSSTLKSLENKEKIHRMLDKITDALIWYMAKSGLSLQQQHQR
LAQLLLILSHIRHMSNKGMEHLYSMKSKNVVPLSDLLLEMLDAHR
3D structure
PDB7nel A PROSS-designed extensively mutated estrogen receptor alpha variant displays enhanced thermal stability while retaining native allosteric regulation and structure.
ChainB
Resolution1.45 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B I358 K362 L372 V376 E380 D538 L539 E542 M543 I55 K59 L69 V73 E77 D235 L236 E239 M240
BS02 EST B E353 L387 F404 H524 L525 E50 L84 F101 H221 L222 BindingDB: IC50=1.3nM,Kd=0.2nM,EC50=0.75nM,Ki=0.21nM
External links
PDB RCSB:7nel, PDBe:7nel, PDBj:7nel
PDBsum7nel
PubMed34006920
UniProtP03372|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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